Lipid Composition and Structural Organization Flashcards
Interactions holding together lipid bilayer:
Van der Waal & hydrophobic
3 Classes of Lipids
Phosphoglycerides, Sphingolipids, & Cholesterol (Sterol)
Phosphoglyceride
hydrophobic tail, glycerol-3-phosphate, & polar head group
Sphingolipid
made up of sphingosine, fatty acyl chain, amino alcohol, & polar head group
Cholesterol/Sterol
ring structure with hydroxyl head group
Factors affecting bilayer fluidity:
lipid composition, structure of tails (shorter tails/double bonds=increased fluidity), temperature, cholesterol content (inhibits fluidity)
Site of phosphoglyceride synthesis
cytosolic side of endoplasmic reticulum
Site of Sphingolipid synthesis
exoplasmic face (luminal side) of Golgi complex
Lipids abundant in membrane outer leaflet
sphingomyelin & phosphatidylcholine
Lipids abundant in membrane inner leaflet
phosphatidylethanolamine, phosphatidylserine, & phosphatidylinositol
Lipids evenly distributed between membrane leaflets
cholesterol
Flippase
enzyme that can move certain phospholipids from one leaflet to the other; ATP dependent