Linkage

Question 1

Principle of Segregation

Answer 1

Alleles separate during meiosis

Question 2

Independent Assortment

Answer 2

Alleles at one locus sort independently from alleles at another locus. Need to be on different chromosomes or far away from each other on the same chromosome.

Question 3

Recombination

Answer 3

Alleles sort into new combinations due to crossing over in Prophase 1 of meiosis `

Question 4

Genetic Linkage

Answer 4

the tendency of DNA sequences that are close together on a chromosome to be inherited together.

Question 5

Coupling (cis configuration)

Answer 5

One chromosome contains both wild types alleles, one chromosome contains both mutant alleles

Question 6

Repulsion (trans configuration)

Answer 6

Wild-type allele and mutant allele are found on the same chromosome

Question 7

Recombination Frequency

Answer 7

allows us to predict expected offspring for a cross with linked genes
= (# of recombinant progeny/ total # of progeny) x 100%

Question 8

Chi-square analysis

Answer 8

test for independence determines if two genes are sorting independently