Lincosamides

Question 1

MOA?

Answer 1

Act by reversibly binding to the 50S ribosomal subunit at the 23S portion of the subunit inhibiting bacterial biosynthesis

Question 2

Spectrum of activity?

Answer 2

G(+)

Question 3

What tier do these belong to?

Answer 3

Tier2/3

Question 4

What are some indications to use these drugs?

Answer 4

Bone infections, periodontal disease, URTI, skin

Question 5

What specific bacteria can they be useful against?

Answer 5

Penicillin-resistant Stap and strep, actinomyces, nocardia, myocoplasma, fusobacterium, bacteriodes

Question 6

What are some mechanisms of resistance?

Answer 6

Active efflux mechanism in some bacteria, methylase enzyme which modifies ribosomal target, hydrolysis of macrolides by esterases, chromosomal mutation of ribosomal binding sites

Question 7

What is the distribution?

Answer 7

Good bone penetration

Poor distribution in eye (unless meninges are inflamed)

Question 8

What are some examples of these drugs?

Answer 8

Lincomycin and Clindamycin

Question 9

What is lincomycin used for?

Answer 9

Used as a feed additive in poultry

Question 10

What bacteria is clindamycin used against?

Answer 10

G(+) anaerobic bacteria, toxoplasma and neospora