Lincosamides

Question 1

static or cidal

Answer 1

static

Question 2

2 drug names in this group

Answer 2

1) lincomycin

2) clindamycin

Question 3

Which of the 2 drugs is more effective?

Answer 3

clindamycin

Question 4

Which of the 2 drugs is broad spectrum?

Answer 4

clindamycin

Question 5

Which of the 2 drugs is more lipid soluble?

Answer 5

clindamycin

Question 6

Which of the 2 drugs has an active metabolite?

Answer 6

clindamycin

Question 7

MOA for lincosamides

Answer 7

they enter cell and bind to the 50S ribosomal subunit, inhibiting translocation of peptides

Question 8

Which drug is responsible for the interference with the attachment and entry of TOXO gondii tachyzoites in host cells?

Answer 8

Clindamycin

Question 9

Do macrolides and lincosamides compete for the site of action?

Answer 9

Yes, antagonism.

Question 10

What is the spectrum for Lincomysin?

Answer 10

Gram+ aerobic.
Mycoplasma
NOT GRAM-!! but we can get around this…

Question 11

Is it possible to treat G- with Lincomysin? If so, how?

Answer 11

Lincomycin AND spectinomycin used to treat G+/- mainly in swine and poultry

Question 12

What is the spectrum for Clindamycin?

Answer 12

Gram+ and Gram-
Anaerobes
TOXO gondii

Question 13

Lincomysin absorption is rapid and complete or incomplete?

Answer 13

incomplete

Question 14

Can Lincomysin be given with food?

Answer 14

NO

Question 15

Clindamycin absorption complete or incomplete?

Answer 15

Complete and high as well

Question 16

Can Clind be given with food?

Answer 16

Not a problem

Question 17

Parenteral IM: rapid and complete absorption for either drugs or both drugs?

Answer 17

BOTH

Question 18

Are Lincosamides acids or bases?

Answer 18

Bases

Question 19

Great or not so great distribution in the body?

Answer 19

great! they get high tissue concentrations even in respiratory secretions, bones, joints…etc

Question 20

Which of the 2 drugs could be used to treat meningoencephalitis?

Answer 20

Clindamycin! because it can pass the BBB and reach high concentration. Can also cross the placental barrier.

Question 21

How are the drugs metabolized?

Answer 21

Clindamycin: oxidized in the liver
Lincomycin: not important

Question 22

Clindamycin has 2 active metabolites. What are they?

Answer 22

1) N-demethylclindamycin

2) Clindamycin sulfoxide

Question 23

How are these drugs excreted?

Answer 23

Bile is primary route

Urine is secondary route

Question 24

Overall side effects associated with this group of drugs?

Answer 24

Generally safe with a bit of diarrhea in dogs and vomiting in cats BUT……

Question 25

ORAL ADMINISTRATION IS CONTRAINDICATED IN which animals?

Answer 25

chinchillas, G pigs, hamsters, horses, ponies and rabbits

Question 26

Why can’t we give oral route to the fur babies?

Answer 26

because the drugs alter the GI flora resulting awful enterocolitis.

Question 27

Lincomycin specifically causes what reaction in which animals?

Answer 27

Enterocolitis in rabbits, horses, sheep and large ruminants

Ketosis in dairy cows

Question 28

Bacterial resistance is in the form of

Answer 28

efflux mechanism and ribosomal alteration

Question 29

Can get cross reaction with

Answer 29

MLC

macrolides lines and chloramphenicols

Question 30

Is this group of drugs Type 1 2 or 3?

Answer 30

Type 2!!! 2 for 2 drugs