Limbic System - Engeland

Question 1

List current depression meds and how they work:

Answer 1

MAO inhbitors - Block degadation 5-HT and NE in synapse

Tricyclics: Block reuptake of 5HT and NE

SSRI’s - 5HT reuptake inhbiition

Question 2

Strange symptoms of Kluver-Bucy Syndrome:

Answer 2

Oral tendencies
Changes in emotions
Hypersexuality
Visual Agnosia

Question 3

Main structural damage in Korsakoff’s sysdnorme:

Answer 3

Mammillary bodies

Question 4

Treatment that attempts to provide relief from symptoms of Alzhiemer’s?

Answer 4

ACh-esterase blocker

to increase ACh

Question 5

What causes Chronic Traumatic Encephalopathy?

Answer 5

Repeated head trauma

effects on:
cognition
mood - (depression and apathy)
behavior (impulse and aggressiveness increase)

Question 6

What stuff makes you want to eat less?

Answer 6

Gastric distention
CCK in intestines
Leptin from fast stores
Melanocortin
CRH

Question 7

What gentic disease causes hypersecretion of ghrelin?

Answer 7

Prader Willi Syndrome

Question 8

What does Ghrelin do?

Answer 8

Released in response to fasting, increases appetite!

Question 9

What caused problems in studies lesioning the LHA and assuming that is caused decreased appaetite?

Answer 9

They would lesion the medial forebrain bundle too… and that would just make them not want to move so much…

Question 10

If you isolated and increased LHA actvity, what would happen?

Answer 10

You would produce orexin and increase eating and growth

Question 11

What stuff makes you want to eat more?

Answer 11

Ghrelin, NPY, Orexin