Lifespan Midterm Flashcards
Over the past 20-30 years special emphasis has been directed towards which four subgroups?
WORE
-women, oldest old (over 85)/ frail elderly or extremely old, racial minor ties, ethnic minorities
Overall the _ _ is rising.
Overall the MEDIAN AGE is rising
Mortality patterns: _ of all deaths occur at age _ or _, expected to be _ by 2030. _ of all deaths occur at age _ or _, expected to rise by _% by 2050.
70% of all deaths occur at age 65 or OLDER, expected to be 80% by 2030.
18% of all deaths occur at age 85 or OLDER, expected to rise by to 43% by 2050.
The US census bureau defines: 55-64 as _. 65-84 as _. 85+ as _.
55-64 as OLDER
65-84 as ELDERLY
85+ as OLDEST OLD
Gender composition: age 65 and older- women _ men :; age 85 and older- women _ men :.
Age 65 and older- women OUTNUMBER men 3:2
Age 85 and older- women OUTNUMBER men 5:2
Marital status: _ of males over 65 are married. _ of females over age 65 are widowed.
75% of males over 65 are married
65% of females over 65 are widowed
What is the divorce rate for those 65 or older? Is on the _ over the past two decades. Remarriages? Is on the _ over the past decade.
7% divorce rate for those over 65 or older
Is on the RISE over the past two decades.
Remarriage a had been SIGNIFICANTLY LOW
Is on the RISE over the past decade
Proportion of never-married males? Females?
Both are approx. 12.5%
Living arrangements: 60% of women over the age of 75 live _. 80% of men over 65 live?
60% of women over the age of 75 live ALONE
80% of men over 65 live WITH ANOTHER FAMILY MEMBER
What is the current life expectancy? Projected trends by 2050?
- 3 years- current
82. 5 years- projected trends
Not all _ _ age at the same rate. There is no _ _ theory of aging.
Not all SOMATIC CELLS age at the same rate
There is no UNIVERSALLY ACCEPTED theory of aging
Senescence is defined as _, _ _ in aged organisms that predispose them to _ _ and _.
Senescence is defined as NONREVERSIBLE, DETERIORATED CHANGES in aged organisms that predispose them to FATAL DISEASE and DEATH
3 Somatic cell catagories?
F RC
- fixed postmiotic cells
- reverting postmiotic cells
- continuously proliferating cells
Continuously proliferating cells _ _ to replicate themselves, these cells _ through _.
Continuously proliferating cells NEVER CEASE to replicate themselves, these cells HEAL THROUGH REGENERATION
Reverting postmiotic cells have a _ _ of division, when injured will _ _ the _ of _ and _.
Reverting postmiotic cells have a SLOWER RATE of division, when injured will SPEED UP the RATE OF DIVISION AND REGENERATION.
Fixed postmiotic cells _ _ after _, only able to _ _ if the _ is intact. _ _ cells are produced.
Fixed postmiotic cells NEVER REPLICATE after MATURITY, only able to REPAIR THEMSELVES if the NUCLEUS is intact.
NO NEW cells are produced.
What type of somatic cell are kidney and liver cells?
Reverting postmiotic cells
What type of somatic cells are lung, cardiac?
Fixed postmiotic cells
What type of somatic cells are superficial skin cells, intestinal lining, RBC’s, and bone marrow?
Continuously proliferating cells
What two specific types of cells are controversially considered fixed postmiotic cells?
Muscle and neuron cells
According to the _/ _ theories the mechanism of aging is predetermined and located in the nucleus, and is genetically controlled. AKA?
According to the DEVELOPMENTAL/ GENETIC THEORIES the mechanisms . . . .
AKA: PROGRAMMED THEORIES
What are the 4 theories that are considered developmental/ genetic/ programmed theories?
THEN
- Telometric theory
- Hayflick Limit theory
- Error and Repair theory
- Neuroendocrine theory
Neuroendocrine theory states that the --_ _ (_) controls aging, and acts through _ to control the _ of aging.
States that the HYPOTHALMIC- PITUITARY- ADRENAL AXIS (HPA) controls aging, and acts through HORMONES to control the PACE of aging.
With the Neuroendocrine theory, the _ regulates the release of various hormones throughout the body. Hormones affect _, _, _ _, _, and _. Example in the body?
Neuroendocrine theory, the HYPOTHALAMUS regulates the release of various hormones throughout the body.
Hormones affect (G MIST) GROWTH, METABOLISMS, INFLAMMATION, STRESS and TEMPERATURE REGULATION.
Example: MENOPAUSE
According to the error and repair theory the production of _ and the _ of _ is not always carried out with accuracy.
According to the error and repair theory the production of PROTEINS and the REPRODUCTION OF DNA is not always carried out with accuracy.
Error and repair theory: the system is incapable of _ _ _ every time, therefore the _ of these _ _ leads to _ of the organism.
The system is incapable of MAKING PERFECT REPAIRS every time, therefore the ACCUMULATION of these FLAWED DNA leads to SENESCENCE of the organism
The _ _ theory studied cell division in lung tissue and discovered that cells are able to replicate - times.
The HAYFLICK LIMIT theory studied cell division in lung tissue and discovered that cells are able to replicate 40-60 TIMES.
According to Hayflick limit theory cells begin to _ _ toward the end of their _ to _. These changes include?
Cells begin to LOOK DIFFERENT toward the end of their ABILITY TO REPLICATE.
These changes include LIPOFUSCIN (age pigments)
The _ _ is an extension of the Hayflick Limit theory, and states that in the normal process of _ _, the end of the chromosome is _ _ _ , which leaves and _ _.
The TELOMERIC THEORY is an extension of the Hayflick limit theory, and states that in the normal process of DNA REPLICATION, the end of the chromosome is NOT COPIED EXACTLY, which leaves an UNREPLICATED GAP.
According to the Telemeric theory the _ _ with each cell division, when the become _ _ the cells enters the _ stage.
The TELOMERES SHORTEN with the each cell division, when the become TOO SHORT the cells enter the SENESCENCE.
Shortened telomeres are found in? (4)
AH CH
- Atherosclerosis
- Heart disease
- cirrhosis
- hepatitis
As long as the cells have telomerase, they keep enough telomerase, which prevents _ from _. _% of _ cells have been found to possess telomerase.
They keep enough telomerase, which prevents TELOMERES from SHORTENING.
90% of CANCER cells have been found to possess telomerase.
Research of Telomerase: _ telomerase may help _ _, and stripping it may _ _. Telomerase may also be used to help with _ _ or the _ _.
MEASURING telomerase may help DETECT CANCER, and stripping it may FIGHT CANCER.
Telomerase may also be used to help with WOUND HEALING or the IMMUNE RESPONSE.
/ theories believe that aging is caused by insults in the environment that have an effect on organs and the body systems. AKA?
STOCHASTIC/ NON-GENETIC theories believe that. . .
AKA: Random Theories
What are the 4 stochastic/ non-genetic/ random theories?
IS Fuckin Crazy
- Immunological theory
- somatic mutation theory
- free radical theory
- cross-linkage theory
Somatic mutation theory states that genetic _ results from exposure to _. Became popular in the _ _ _ era. Later studies showed?
Theory states that genetic MUTATION results from exposure to RADIATION.
Became popular in the POST WW II era.
Later studies showed the radiation-induced changes were only mimicking age changes.
According to immunological theory states that with age the systems ability to _ _ _ that fight diseases declines as a result of _ _ _ _. System begins to lose ability to distinguish between _ and _.
Theory states that with age the systems ability to PRODUCE NECESSARY ANTIBODIES that fight diseases declines as result of DECREASED T CELL FUNCTION.
Example set of immunological theory of autoimmune diseases are _, _, and adult-onset _.
Autoimmune diseases are LUPUS, SCLERODERMA, and adult-onset DIABETES
Cross-linkage theory is also referred to as the _ _ of aging. Believes that it is the _ of _ to _ that causes various problems. The accumulation of _ _ _ damage cells and tissue, slowing down bodily process.
Also referred to as the GLYCOSYLATION THEORY of aging.
Believes that is the accumulation of CROSS LINKED PROTEINS damage cells and tissue, slowing down bodily process.
2 examples in the body cited for the cross linkage theory: loss of _ of _ tissue, and _ changes in the _.
Loss of FLEXIBILITY OF CONNECTIVE tissue
MICROVASCULAR changes in the ARTERIES
The cross linkage of molecules is primarily responsible for _ _ _.
Primarily responsible for SECONDARY AGING EFFECTS.
_ _ are byproducts of chemical reactions in the body that can damage proteins and DNA within the cell.
FREE RADICALS are byproducts of . . . .
Free radicals attack _ _ in fats. If DNA is attacked a _ will occur causing _ or _. If proteins are attacked the _ _ _ and may result in the loss of _ _.
Free radicals attack the CELL MEMBRANE in fats.
If DNA is attacked a MUTATION will occur causing CANCER or AGING
If proteins are attacked the PROTEIN BREAKS DOWN and may result in the loss of BIOLOGICAL FUNCTION
The free radical theory of aging proposes that _ _ _, small amounts of _ _ and _ to deterioration of _ and _.
Proposes that LITTLE BY LITTLE, small amounts of DAMAGE ACCUMULATE and CONTRIBUTE to deterioration of ORGANS AND TISSUES.
Under normal conditions _ _ _ prevent most of the oxidative damage (free radicals) from occuring.
Under normal conditions NATURAL DEFENSE MECHANISMS prevent most of the . . . .
Natural defense mechanisms that help prevent oxidation include: _ _, such as bilirubin; _ such as superoxide dismutase (SOD), catalase, and glutathione per oxidase; _ _ such as beta carotene, Vitamin C and E.
Include:
- NATURAL ANTIOXIDANTS such as bilirubin
- ENZYMES suck as superoxide dismutase . . .
- DIETARY ANTIOXIDANTS such as beta carotene . . .
There is currently _ _ _ that explains the entire process of growing old. Age is much better explained when a _ _ _ are _.
There is currently NO SINGLE THEORY that explains the entire process of growing old.
Age is much better explained when a NUMBER OF THEORIES ARE INTEGRATED.
If you see a rapid decline in function/ rapid change it is most likely due to? (4) AKA?
AKA: 4 -tions
IM DD
- infection
- medication (change in dosage and/ or new meds)
- depression
- dehydration
The normal aging process is observed as a _ _ in _. AKA?
Is observed as a SLOW DECREMENT IN FUNCTION
AKA: Eugeric