Life Cycle of COVID Flashcards
1
Q
Life cycle of coronavirus
A
1) binding + entry via membrane fusion or endocytosis
2) translation of viral polypeptide, leads to autoproteolysis and co-translational cleavage to make nsps proteins
3) forms RdRp complex with help from ORF1a and ORF1b proteins
4) (-sense) subgenomic transcription and RNA replication
5) (+sense) subgenomic transcription and RNA replication (4 and 5 forms mRNA transcript)
6) translate subgenomic mRNA into proteins (M,E,N,S)
7) nucleocapsid (N) buds into ERGIC studded with M,E,S proteins
8) formation of virion in exocytotic vesicle
9) vesicle fuses with membrane, releases virion contents via exocytosis
