Lichen planus Flashcards
the 5 skin variants of LP
Hypertrophic LP
Follicular LP
Vesicular LP
Actinicus LP
Ulcerative LP
What type of immune cell infiltrate is in lichen planus
CD8 mostly
What is the characteristic lymphocytic infiltrative pattern?
Sawtooth lymphocyte infiltrate at the dermal epidermal junction.
What are the oral lesions like in LP
Reticular - Whickham stria white lines
Erosive or ulcerative - superficial erosions, desquamative gingivitis.
How does LP affect the hair on its patches, how does this differ from psoriasis
LP causes scarring alopecia on the scalp, psoriasis does not cause hair loss.
Nail changes
Nail destruction with longitudinal splintering
Sometimes nails are the only part involved in lP, with all 20 involved and no other symptoms.
What is the histology changes of LP.
What disease does it share a similarity with?
Hyperkeratosis and hypergranulosis. Mild parakeratosis is also possible.
Liquifactive necrosis in the basal cell layer.
- Basal cell degeneration and vacuolization is also seen in SLE skin lesions.
Sawtooth infiltration of mostly CD8 lymphocytes.
Band-like infiltration of mononuclear cells.
Depostis of fibrin and IgM.
What systemic diseases are LP associated with?
Mainly Hepatitis C
Also lichenoid GVHD and lichenoid drug eruptions
Treatment of LP
Topical glucocorticoids
Topical cyclosporine and tacrolimus
Oral cyclosporine or glucocorticoids
PUVA
Myucophenolate, Azathiaprine.
