Leukotriene Receptor Antagonists

Question 1

Actions

Answer 1

Selectively and competitively block or antagonize receptors for the production of leukotrienes

They do not have an immediate effect

Question 2

Indications

Answer 2

Prophylaxis and chronic treatment of bronchial asthma

Question 3

Drug names

Answer 3

“-lukast”
Zafirlukast
Montelukast

Question 4

Contraindication

Answer 4

Acute asthma attack

Question 5

Caution

Answer 5

Hepatic or renal impairment

Pregnancy and lactation

Question 6

Adverse effects

Answer 6

URI, pharyngitis, cough

CNS: Headache, dizziness

GI: nausea, diarrhea, vomiting, abdominal pain, elevated liver enzymes
generalized pain, fever, myalgia

Mood changes

Question 7

Drug-Drug Interactions

Answer 7

Propranolol, theophylline, terfenadine, warfarin, calcium channel blockers, cyclosporine, or aspirin

Question 8

Assessment

Answer 8

History
	Contraindications: 
         Allergy, acute 
         bronchospasm or 
         asthmatic attack
	Caution: Impaired 
         renal or hepatic 
         function, pregnancy 
         and lactation

Physical
	Temperature, 
         respirations, and lung 
         sounds
	CNS: Orientation and 
        affect
	Abdominal evaluation

Labs: liver and renal function tests

Question 9

Diagnosis

Answer 9

Risk for injury
Acute pain
Deficient knowledge

Question 10

Implementation

Answer 10

Take on an empty stomach
Safety measures
Patient teaching