Leukotriene Modifiers, Mast Cell Stabilizers, COPD Standards & Antihistamines

Question 1

zafirlukast, zileuton and montelukast

Answer 1

leukotriene modifiers

Question 2

leukotriene modifier prototype

Answer 2

zafirlukast

Question 3

are leukotriene modifiers oral or inhaled?
which class do they belong to (bronchodilators or antiinflammatory)?

Answer 3

all oral

antiinflammatory

Question 4

oral drug used for treating chronic asthma, NOT indicated for symptoms of acute attack

Answer 4

leukotriene modifiers

Question 5

leukotriene modifiers require what test prior to use? and should you be monitoring for toxicity?

Answer 5

LFTs - hepatotoxic.

signs of liver toxicity (nausea, anorexia, abd. pain)

Question 6

headache, gastritis, depression, suicidal behavior, hallucinations and neuropsychiatric symptoms are adverse effects of what drug class?

Answer 6

leukotriene modifiers

Question 7

interactions with theophylline, aspirin, and warfarin occur with what drug class?

Answer 7

leukotriene modifiers

Question 8

churg-strauss syndrome can occur when glucocorticoid dosage is reduced or withdrawn with what drug class?

Answer 8

leukotriene modifiers

Question 9

cromolyn belongs to what drug class?

is it a bronchodilator or an antiinflammatory?

Answer 9

mast cell stabilizers

antiinflammatory

Question 10

this med suppresses inflammation, but does NOT cause bronchodilation

Answer 10

cromolyn

Question 11

inhalation agent that suppresses bronchial inflammation and is used as PROPHYLAXIS (not quick relief) in patients with mild to moderate asthma, as well as EIB & allergic rhinitis

Answer 11

cromolyn

Question 12

cough or bronchospasm could occur as a side effect of this inhaled antiinflammatory

Answer 12

cromolyn

Question 13

GOLD Standards for COPD include:
Group A
Group B
Group C
Group D
What is the FEV1 for each group?

Answer 13

A: >80%
B: 50-79&
C: 30-49&
D: <30%

Question 14

What drugs should be used for Group A and Group B according to GOLD standards?

Answer 14

Group A: bronchodilator (SABA, LABA, LAMA, SAMA)

Group B: LABA or LAMA

Question 15

What drugs should be used for Group C and Group D according to GOLD standards?

Answer 15

Group C: LAMA

Group D: LAMA or LAMA + LABA or LABA + ICS

Question 16

diphenhydramine belong to which generation of H1 antagonists?

Answer 16

1st generation

Question 17

loratidine, fexofenidine, certrizine belong to which generation of H1 antagonists? which one is the prototype?

Answer 17

2nd generation

fexofenadine

Question 18

which generation of antihistamines is sedating?

Answer 18

1st generation

Question 19

CNS depression is most common with which 1st generation H1 antagonist?

Answer 19

diphenhydramine

Question 20

what health condition should cautiously be used with diphenydramine?

Answer 20

asthma - thickening of bronchial secretions may impair breathing

Question 21

what are the effects associated with 1st generation H1 antagonists?

Answer 21

anticholinergic effects (dry mouth, constipation, palpitations)

Question 22

what is loratadine used for?

Answer 22

season allergies only

Question 23

which 2nd generation H1 antagonist has delayed absorption with food intake?

Answer 23

loratadine

Question 24

most common effects with loratadine (2)

Answer 24

drowsiness and headache

Question 25

least sedating 2nd generation H1 antagonist

Answer 25

fexofenadine

Question 26

which 2nd generation H1 antagonist is the best combo of efficacy and safety?

Answer 26

fexofenadine

Question 27

with which H1 antagonist should you avoid juices d/t decreased absorption and subtherapeutic effects?

Answer 27

fexofenadine