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HEMATOLOGY 1 > LEUKOPOIESIS PPT > Flashcards

LEUKOPOIESIS PPT Flashcards

1
Q

GROUP OF LEUKOCYTES

A

-Granulocytes/ Polymorphonulear
Cells
- Mononuclear cells

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2
Q

The immune system can recognize and identify various types of pathogens

A

Pathogen recognition

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3
Q

Triggers an inflammatory response to isolate and remove pathogens or damaged tissues

A

Inflammation response

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4
Q

The immune system maintains self-tolerance, between self and non-self

A

Autoimmune regulation

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5
Q

Myoblast make up ____ of the nucleated cells in the bone marrow and measure _____ in diameter.

A

0% to 3% and 14 to 20 mm

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6
Q

Myoblast are often subdivided into:

A

type I, type II, and type III

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7
Q

High nucleus-to-cytoplasm (N:C) ratio of 8:1 to 4:1

A

Type I Myeloblast

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8
Q

Slightly basophilic cytoplasm

A

Type I Myeloblast

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9
Q

Fine nuclear chromatin

A

Type I Myeloblast

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10
Q

Two to four visible nucleoli

A

Type I Myeloblast

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11
Q

No visible granules

A

Type I Myeloblast

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12
Q

Presence of dispersed primary (azurophilic) granules in the cytoplasm; number of granules does not exceed 20 per cell.

A

Type II Myeloblast

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13
Q

Darker chromatin and a more purple cytoplasm

A

Type III Myeloblast

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14
Q

Contain more than 20 granules that do not obscure the nucleus.

A

Type III Myeloblast

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15
Q

Rare in normal bone marrows, but they can be seen in certain types of acute myeloid leukemias.

A

Type III Myeloblast

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16
Q

Comprise 1% to 5% of the nucleated cells in the bone marrow.

A

Promyelocyte

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17
Q

Promyelocyte relatively larger than the myeloblast cells and measure
______ in diameter.

A

16 to 25 mm

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18
Q

Nucleus is round to oval and is often eccentric.

A

Promyelocyte

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19
Q

is usually seen in normal promyelocytes but not in the malignant promyelocytes
of acute promyelocytic leukemia.

A

Paranuclear halo or “hof ”

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20
Q

In Promyelocyte cytoplasm is evenly basophilic and full of

A

primary (azurophilic) granules.

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21
Q

Myelocyte make up _____ of the nucleated cells in the bone marrow.

A

6% to 17%

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22
Q

The final stage in which cell division (mitosis) occurs.

A

Myelocyte

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23
Q

Begins to manufacture secondary (specific) neutrophil granules.

A

Myelocyte

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24
Q

Metamyelocyte constitute ______ of nucleated marrow cells.

A

3% to 20%

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25
Q

The nucleus is indented (kidney bean shaped or peanut shaped), and the chromatin is increasingly clumped. Nucleoli are absent.

A

Metamyelocyte

26
Q

Synthesis of tertiary granules (also known as gelatinase granules) may begin during this stage.

A

Metamyelocyte

27
Q

Size of _____ is slightly smaller than that
of the myelocyte (14 to 16 mm)

A

metamyelocyte

28
Q

Make up _______ of nucleated marrow cells and_____ of the nucleated peripheral blood cells.

A

9% to 32% and 0% to 5%

29
Q

Secretory granules (also known as secretory vesicles) may begin to be formed during this stage.

A

Bands

30
Q

The nucleus is highly clumped, and the nuclear indentation that began in the metamyelocyte stage now exceeds one half the diameter of the nucleus, but
actual segmentation has not yet occurred.

A

Bands

31
Q

Segmented Granulocytes

A

EOSINOPHIL
BASOPHIL
NEUTROPHIL

32
Q

2 nuclear lobes

A

EOSINOPHIL

33
Q

Cytoplasm contains bright orange-red granules

A

EOSINOPHIL

34
Q

Larger than neutrophils

A

EOSINOPHIL

35
Q

Polymorphic nucleus

A

BASOPHIL

36
Q

Cytoplasm has large blue- black granules

A

BASOPHIL

37
Q

Cytoplasm has large blue- black granules

A

BASOPHIL

38
Q

2- 5 nuclear lobes connected by thread-like filaments

A

NEUTROPHIL

39
Q

Present in the highest numbers in the peripheral blood of adults

A

NEUTROPHIL

40
Q

Light pink- blue cytoplasm

A

NEUTROPHIL

41
Q

12- 20 um

A

Monoblast

42
Q

Large, round or ovoid nucleus

A

Monoblast

43
Q

Deep blue cytoplasm without granules

A

Monoblast

44
Q

12- 18 um in diameter

A

Promonocyte

45
Q

Nucleus is slightly indented or folded with at least one nucleolus present

A

Promonocyte

46
Q

With small and large lilac azurophilic dust granules

A

Promonocyte

47
Q

Largest cell in the peripheral blood smear (PBS); 15-20 um in diameter.

A

Monocyte

48
Q

Nucleus may be round, oval, or kidney shaped but more often is deeply indented (horseshoe shaped) or folded on itself.

A

Monocyte

49
Q

Cytoplasm is blue-gray, with fine azure granules often referred to as azure dust or a ground-glass appearance.

A

Monocyte

50
Q

Slightly immature cells whose ultimate goal is to enter the tissues and mature into macrophages, osteoclasts, or dendritic cells.

A

Monocyte

51
Q

Nucleus: large, oval with dark purple chromatin

A

Lymphoblast

52
Q

Cytoplasm: deep blue, 1-2 nucleoli

A

Lymphoblast

53
Q

Not present in peripheral blood, only in the bone marrow

A

Lymphoblast

54
Q

Nucleus: ovoid with occasional indented border

A

Prolymphocyte

55
Q

Cytoplasm: light – dark blue with one nucleoli

A

Prolymphocyte

56
Q

Nucleus: indentation is variable; round shaped,eccentrically located

A

Lymphocyte

57
Q

Cytoplasm: robin’s egg blue. Size vary from small (7-9μm) to large (8-16 μm)

A

Lymphocyte

58
Q

Innate immunity as phagocytes

A

Neutrophil

59
Q

Allergic reactions, helminth destruction
& immunity against ticks

A

Basophil

60
Q

Allergic reactions & helminth destruction

A

Eosinophil

61
Q

Adaptive immunity

A

Lymphocyte

62
Q

Precursors to tissue cells that perform
phagocytosis

A

Monocyte

HEMATOLOGY 1 (4 decks)

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