LEUKOPOIESIS PPT

Question 1

GROUP OF LEUKOCYTES

Answer 1

-Granulocytes/ Polymorphonulear
Cells
- Mononuclear cells

Question 2

The immune system can recognize and identify various types of pathogens

Answer 2

Pathogen recognition

Question 3

Triggers an inflammatory response to isolate and remove pathogens or damaged tissues

Answer 3

Inflammation response

Question 4

The immune system maintains self-tolerance, between self and non-self

Answer 4

Autoimmune regulation

Question 5

Myoblast make up ____ of the nucleated cells in the bone marrow and measure _____ in diameter.

Answer 5

0% to 3% and 14 to 20 mm

Question 6

Myoblast are often subdivided into:

Answer 6

type I, type II, and type III

Question 7

High nucleus-to-cytoplasm (N:C) ratio of 8:1 to 4:1

Answer 7

Type I Myeloblast

Question 8

Slightly basophilic cytoplasm

Answer 8

Type I Myeloblast

Question 9

Fine nuclear chromatin

Answer 9

Type I Myeloblast

Question 10

Two to four visible nucleoli

Answer 10

Type I Myeloblast

Question 11

No visible granules

Answer 11

Type I Myeloblast

Question 12

Presence of dispersed primary (azurophilic) granules in the cytoplasm; number of granules does not exceed 20 per cell.

Answer 12

Type II Myeloblast

Question 13

Darker chromatin and a more purple cytoplasm

Answer 13

Type III Myeloblast

Question 14

Contain more than 20 granules that do not obscure the nucleus.

Answer 14

Type III Myeloblast

Question 15

Rare in normal bone marrows, but they can be seen in certain types of acute myeloid leukemias.

Answer 15

Type III Myeloblast

Question 16

Comprise 1% to 5% of the nucleated cells in the bone marrow.

Answer 16

Promyelocyte

Question 17

Promyelocyte relatively larger than the myeloblast cells and measure
______ in diameter.

Answer 17

16 to 25 mm

Question 18

Nucleus is round to oval and is often eccentric.

Answer 18

Promyelocyte

Question 19

is usually seen in normal promyelocytes but not in the malignant promyelocytes
of acute promyelocytic leukemia.

Answer 19

Paranuclear halo or “hof ”

Question 20

In Promyelocyte cytoplasm is evenly basophilic and full of

Answer 20

primary (azurophilic) granules.

Question 21

Myelocyte make up _____ of the nucleated cells in the bone marrow.

Answer 21

6% to 17%

Question 22

The final stage in which cell division (mitosis) occurs.

Answer 22

Myelocyte

Question 23

Begins to manufacture secondary (specific) neutrophil granules.

Answer 23

Myelocyte

Question 24

Metamyelocyte constitute ______ of nucleated marrow cells.

Answer 24

3% to 20%

Question 25

The nucleus is indented (kidney bean shaped or peanut shaped), and the chromatin is increasingly clumped. Nucleoli are absent.

Answer 25

Metamyelocyte

Question 26

Synthesis of tertiary granules (also known as gelatinase granules) may begin during this stage.

Answer 26

Metamyelocyte

Question 27

Size of _____ is slightly smaller than that of the myelocyte (14 to 16 mm)

Answer 27

metamyelocyte

Question 28

Make up _______ of nucleated marrow cells and_____ of the nucleated peripheral blood cells.

Answer 28

9% to 32% and 0% to 5%

Question 29

Secretory granules (also known as secretory vesicles) may begin to be formed during this stage.

Answer 29

Bands

Question 30

The nucleus is highly clumped, and the nuclear indentation that began in the metamyelocyte stage now exceeds one half the diameter of the nucleus, but actual segmentation has not yet occurred.

Answer 30

Bands

Question 31

Segmented Granulocytes

Answer 31

EOSINOPHIL BASOPHIL NEUTROPHIL

Question 32

2 nuclear lobes

Answer 32

EOSINOPHIL

Question 33

Cytoplasm contains bright orange-red granules

Answer 33

EOSINOPHIL

Question 34

Larger than neutrophils

Answer 34

EOSINOPHIL

Question 35

Polymorphic nucleus

Answer 35

BASOPHIL

Question 36

Cytoplasm has large blue- black granules

Answer 36

BASOPHIL

Question 37

Cytoplasm has large blue- black granules

Answer 37

BASOPHIL

Question 38

2- 5 nuclear lobes connected by thread-like filaments

Answer 38

NEUTROPHIL

Question 39

Present in the highest numbers in the peripheral blood of adults

Answer 39

NEUTROPHIL

Question 40

Light pink- blue cytoplasm

Answer 40

NEUTROPHIL

Question 41

12- 20 um

Answer 41

Monoblast

Question 42

Large, round or ovoid nucleus

Answer 42

Monoblast

Question 43

Deep blue cytoplasm without granules

Answer 43

Monoblast

Question 44

12- 18 um in diameter

Answer 44

Promonocyte

Question 45

Nucleus is slightly indented or folded with at least one nucleolus present

Answer 45

Promonocyte

Question 46

With small and large lilac azurophilic dust granules

Answer 46

Promonocyte

Question 47

Largest cell in the peripheral blood smear (PBS); 15-20 um in diameter.

Answer 47

Monocyte

Question 48

Nucleus may be round, oval, or kidney shaped but more often is deeply indented (horseshoe shaped) or folded on itself.

Answer 48

Monocyte

Question 49

Cytoplasm is blue-gray, with fine azure granules often referred to as azure dust or a ground-glass appearance.

Answer 49

Monocyte

Question 50

Slightly immature cells whose ultimate goal is to enter the tissues and mature into macrophages, osteoclasts, or dendritic cells.

Answer 50

Monocyte

Question 51

Nucleus: large, oval with dark purple chromatin

Answer 51

Lymphoblast

Question 52

Cytoplasm: deep blue, 1-2 nucleoli

Answer 52

Lymphoblast

Question 53

Not present in peripheral blood, only in the bone marrow

Answer 53

Lymphoblast

Question 54

Nucleus: ovoid with occasional indented border

Answer 54

Prolymphocyte

Question 55

Cytoplasm: light – dark blue with one nucleoli

Answer 55

Prolymphocyte

Question 56

Nucleus: indentation is variable; round shaped,eccentrically located

Answer 56

Lymphocyte

Question 57

Cytoplasm: robin’s egg blue. Size vary from small (7-9μm) to large (8-16 μm)

Answer 57

Lymphocyte

Question 58

Innate immunity as phagocytes

Answer 58

Neutrophil

Question 59

Allergic reactions, helminth destruction & immunity against ticks

Answer 59

Basophil

Question 60

Allergic reactions & helminth destruction

Answer 60

Eosinophil

Question 61

Adaptive immunity

Answer 61

Lymphocyte

Question 62

Precursors to tissue cells that perform phagocytosis

Answer 62

Monocyte