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HEMATOLOGY 1 > ERYTHROPOIESIS PPT > Flashcards

ERYTHROPOIESIS PPT Flashcards

1
Q

Erythrocyte has one true function:

A

to carry oxygen from the lung to the tissues, where the oxygen is released.

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2
Q

RBCs are formally called

A

erythrocytes

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3
Q

nucleated RBC precursors, normally restricted to the bone marrow

A

Erythroblasts/ normoblasts

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4
Q

Morphologic identification of blood cells depends on a ________

A

well-stained peripheral blood film or bone marrow smear

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5
Q

Commonly used stain/s, in identification of erythroid precursors.

A

Modified Romanowsky stain (Wright or Wright- Giemsa)

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6
Q

The stage of maturation of any blood cell is determined by careful examination of the:

A

nucleus and the cytoplasm.

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7
Q

The most important features in the
identification of RBCs are the:

A

-Nuclear chromatin pattern (texture, density, homogeneity),
- Nuclear diameter
-Nucleus-to-cytoplasm (N:C) ratio
-Presence or absence of nucleoli,
-Cytoplasmic color

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8
Q

The nucleus is round to oval, containing
one or two nucleoli. The purple red chromatin is open and contains few, if any, fine clumps.

A

Pronormoblast (Rubriblast)

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9
Q

The nucleus takes up much of the cell (N:C
ratio of 8:1) in ______

A

Pronormoblast (Rubriblast)

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10
Q

The cytoplasm in Pronormoblast (Rubriblast) is dark blue because of the concentration of?

A

ribosomes and RNA along the periphery.

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11
Q

The pronormoblast undergoes mitosis and gives rise to ?

A

two daughter pronormoblasts

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12
Q

More than one division is possible before maturation into basophilic normoblasts.

A

Pronormoblast (Rubriblast) Division.

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13
Q

Location of Pronormoblast

A

Bone marrow

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14
Q

The pronormoblast begins to accumulate the components necessary for ______ production.

A

hemoglobin production

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15
Q

In pronormoblast the_________ necessary for iron uptake and protoporphyrin synthesis are produced.

A

proteins and enzymes

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16
Q

Globin production begins.

A

Pronormoblast (Rubriblast) celluar activity

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17
Q

Length of time in Pronormoblast stage.

A

lasts slightly more than 24 hours.

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18
Q

The chromatin begins to condense, revealing clumps along the periphery of the nuclear membrane and a few in the interior.

A

Nucleus of Basophilic Normoblast (Prorubricyte)

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19
Q

Basophilic Normoblast (Prorubricyte)
Cytoplasm. When stained, the cytoplasm color may be ________than in the pronormoblast, hence the name basophilic for this stage.

A

deeper, richer blue

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20
Q

N:c ratio decreases to about 6:1

A

Basophilic Normoblast (Prorubricyte)

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21
Q

Basophilic Normoblast (Prorubricyte)
Division. The basophilic normoblast undergoes mitosis, giving rise to?

A

two daughter cells

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22
Q

Basophilic Normoblast (Prorubricyte) location?

A

Bone marrow

23
Q

Basophilic Normoblast (Prorubricyte)
Cellular activity?

A

Detectable hemoglobin synthesis

24
Q

Basophilic Normoblast (Prorubricyte). Length of time in this stage.

A

lasts slightly more than 24 hours.

25
Q

The chromatin pattern varies during this stage of development, showing some openness early in the stage but becoming condensed by the end.

A

Polychromatic (Polychromatophilic) Normoblast (Rubricyte) Nucleus.

26
Q

the condensation of chromatin reduces the diameter of the nucleus , N:C ratio decreases from 4:1 to?

A

1:1 by the end of the stage

27
Q

no nucleoli are present.

A

Polychromatic (Polychromatophilic) Normoblast (Rubricyte) Nucleus.

27
Q

no nucleoli are present.

A
28
Q

Polychromatic (Polychromatophilic)
Normoblast Cytoplasm. The color produced is a mixture of pink and
blue, resulting in

A

murky gray-blue

29
Q

Polychromatic normoblast stage refers to the combination of multiple colors or “many colors” referred as:

A

polychromatophilic

30
Q

This is the last stage in which the cell is capable of undergoing mitosis.

A

Polychromatic (Polychromatophilic)
Normoblast (Rubricyte)

31
Q

Cellular activity. Hemoglobin synthesis increases, and the accumulation begins to be visible as a pinkish color in the
cytoplasm.

A

Polychromatic (Polychromatophilic)
Normoblast (Rubricyte)

32
Q

Length of time in Polychromatic (Polychromatophilic) Normoblast (Rubricyte)

A

stage lasts approximately 30 hours.

33
Q

The nucleus is completely condensed (i.e.,
pyknotic) or nearly so.

A

Orthochromic Normoblast (Metarubricyte)

34
Q

Orthochromic Normoblast (Metarubricyte)
Cellular activity. Hemoglobin production continues on the remaining ribosomes using messenger RNA produced earlier. Late in this stage, the_____ ejected from the cell

A

nucleus

35
Q

Orthochromic Normoblast (Metarubricyte) Length of time in this stage.

A

lasts approximately 48 hours.

36
Q

Beginning at the polychromatic erythrocyte or reticulocytes stage, there is

A

no nucleus

37
Q

Can be compared with that of the late orthochromic normoblast in that the predominant color is that of hemoglobin yet with a______due to some residual ribosomes and RNA.

A

bluish tinge

38
Q

Lacking a nucleus, the polychromatic erythrocyte or reticulocytes

A

cannot divide

39
Q

The polychromatic erythrocyte or reticulocytes resides in the?

A

bone marrow for about 1 to 2 days

40
Q

polychromatic erythrocyte or reticulocytes then moves into the_____ for about 1 day before reaching maturity.

A

peripheral blood

41
Q

The _______completes
production of hemoglobin from a small amount of residual messenger RNA using the remaining ribosomes.

A

polychromatic erythrocyte or reticulocytes

42
Q

Polychromatic (Polychromatophilic)
Erythrocyte or Reticulocyte Length of time

A

remains a polychromatic erythrocyte for about 3 days

43
Q

Polychromatic (Polychromatophilic)
Erythrocyte or Reticulocyte with the first 2
days spent in the___

A

bone marrow

44
Q

Polychromatic (Polychromatophilic)
Erythrocyte or Reticulocyte, the third day spent in the____ although possibly sequestered in the
spleen.

A

peripheral blood,

45
Q

No nucleus is present in mature RBCs.

A

Erythrocyte

46
Q

The mature circulating erythrocyte is a
biconcave disc measuring 7 to 8 mm in diameter.

A

Erythrocyte

47
Q

Erythrocytes on a Wright-stained blood film, it appears as _______stained cell with a central pale area that corresponds to the concavity.

A

salmon-pink

48
Q

The _____ is about one-third the
diameter of the ERYTHROCYTE cell.

A

central pallor

49
Q

The ______ cannot divide.

A

erythrocyte

50
Q

Mature RBCs remain active in the circulation for

A

approximately 120 days.

51
Q

leads to their removal by the spleen as described subsequently.

A

Aging Erythrocytes

51
Q

Orthochromic Normoblast (Metarubricyte) cytplasm . The increase in the _____________ color of the cytoplasm reflects nearly complete hemoglobin
production.

A

salmon pink

51
Q

The orthochromic normoblast is present only in the ______ in healthy states.

A

bone marrow

HEMATOLOGY 1 (4 decks)

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