Leukocytes

Question 1

Neutrophils are comprised of what type of granules?

Answer 1

Azurophilc (lysosomes), specific (contain degradative enzymes) and gelatinase (contain MMPs)

Question 2

Which neutrophil granule contains myeloperoxidase?

Answer 2

Azurophilic granules

Question 3

The majority of granules present in mature neutrophils are which ones?

Answer 3

Specific granules

Question 4

Azurophilic granules.can be divided into:

Answer 4

Defendin rich

Defensin poor

Question 5

What are 2 ways in which Neutrophils differ from macrophages?

Answer 5

Neutrophils do not have prolonged/multiple phagocytosis and neutrophils are terminally differentated

Question 6

What is the neutrophil opsonin receptor?

Answer 6

FC-gamma for IgG heavy chains

Question 7

List the receptors that mediate neutrophil binding to endothelial lining:

Answer 7

Integrins:

1. LFA-1
2. MAC-1
3. CD11c/CD18

L-selectin

Question 8

What’s the major chemotactic agent for neutrophils?

Answer 8

IL-8

Question 9

List the 3 types of complement receptors for neutrophils:

Answer 9

Type 1: CR1 = CD35

Type 3: MAC-1 = CD3 = CD11b/CD18
–binds to ICAM-1 on endothelial cells

Type 4: (similar to Type 3)