General Immuno Flashcards
Discuss the difference between receptors of the innate and adaptive immune systems
innate: limited number of preformed receptors that bind to molecules commonly expressed on many different microbes
adaptive: generates many new structurally-unique receptors that can bind to many many molecules…and collectively recognize molecules on almost any invading microorganism since these are generated randomly; also retains memory of previous exposure and amounts a faster bigger response upon re-exposure (i.e. vaccines)
What cells are engaged in the innate immune system?
macrophages, dendritic cells, neutrophils, NK cells
What cells are engaged in the adaptive immune system?
T and B lymphocytes
T/F: the innate system is specific to common microbial structures
T
T/F: The adaptive immune system is specific to unique antigens.
T
What are examples of the innate immune response?
inflammation, defensivs, lysozyme
what are some examples of the adaptive immune response?
cell-mediated and antibody production
T/F: skin graft rejection is antibody-mediated.
F; cell-mediated
transferrable to normal animals via living cells…can’t transfer graft rejection via serum
What functions occur in the thymus in regards to T cells?
Thymus is the central lymphoid organ where T lymphocytes are:
- educated (achieve specificity),
- selected for histocompatibility complex restriction (positive selection)
- self-tolerance (negative selection)
Antigens in blood circulation are primarily filtered by the ____
spleen
__ of the spleen are T cell domains
periarteriolar sheaths in spleen white pulp
___ of the spleen are B cell domains
adjacent lymph follicles of spleen white pulp.
Marginal zone contains mature noncirculating B cells and dendritic APCs
Tertiary lymphoid tissues include:
Skin-associated lymphoid tissue (SALT), GI (GALT), bronchiolar (BALT), mucosa-associated (MALT)
