Leukemia/Lymphoma Flashcards
What diagnosis should be given to a disease with greater than 20% blasts in bone marrow with blasts in peripheral blood, pancytopenia, variable white blood cell count, occasional Philadelphia chromosome?
ALL (acute lymphoblastic leukemia)
Who usually gets ALL?
Children and older white males
Which leukemic disease is treated with blood transfusions, radiation, chemotherapy, bone marrow transplant?
ALL
Which disease is often idiopathic but can be linked to chemo, radiation, benzene exposure, or tobacco use?
AML (acute myeloid leukemia)
Which disease presents with fever, infection, bleeding, bruising, gingival hyperplasia, ocular hemorrhages, DIC?
AML (acute myeloid leukemia)
Which disease can be diagnosed based on pancytopenia, greater than 20% blasts in bone marrow and some in peripheral blood, leukocytosis, blasts on peripheral smear, Auer rod presence?
AML (acute myeloid leukemia)
What disease presents with anemia, fatigue, fever, infection, mucosal bleeding, hepatosplenomegaly, lymphadenopathy, bone pain, testicular enlargement, gingival hyperplasia?
ALL (acute lymphoblastic leukemia)
Which disease is treated with chemotherapy and BMT?
AML (acute myeloid leukemia)
Who most often gets AML?
White males over age 65
What are three possible complications of AML?
Hyperviscosity syndrome, tumor lysis syndrome, neutropenic fever
Which symptoms qualify as neutropenic fever? How should it be treated?
Fever greater than 100.4 with neutropenia – treat with antibiotics empirically
Which disease is 25% asymptomatic with some experiencing B symptoms, lymphadenopathy, hepatosplenomegaly, leukemia cutis, glomerulonephritis?
CLL (chronic lymphoblastic leukemia)
Which disease can be diagnosed based on B cell lymphocytosis, smudge cells, anemia, thrombocytopenia, neutropenia, infiltrating leukemic cells in bone marrow?
CLL (chronic lymphoblastic leukemia)
Which leukemic disease has no survival benefit for early treatment but most will eventually require chemo?
CLL (chronic lymphoblastic leukemia)
What is a typical CLL patient?
Older males
Name three complications of CLL
Immune defects, immunothrombocytopenic purpura, squamous cell carcinomas (skin cancer)
Which leukemic disease has three phases: chronic, accelerated, and blast crisis?
CML (chronic myeloid leukemia)
Which leukemic disease has 20 to 50% asymptomatic patients, fatigue, abdominal fullness, excessive sweating, weight loss, bleeding, bone pain, splenomegaly, gouty arthritis?
CML (chronic myeloid leukemia)
Which disease has diagnostic criteria of elevated white blood count, Philadelphia chromosome, mostly neutrophils but can also be basophils and eosinophils, low number of blasts, myeloid hyperplasia?
CML (chronic myeloid leukemia)
Which leukemic disease is treated with a tyrosine kinase inhibitor?
CML (chronic myeloid leukemia)
What is the risk factor of CML?
Ionizing radiation
Who typically gets CML?
Males around 50 to 60 years old
What disease has B symptoms, painless lymphadenopathy, shortness of breath, pruritus, alcohol intolerance, decrease in performance status?
Hodgkin’s lymphoma
Which diagnosis is suspected with painless lymphadenopathy, Reed Sternberg cells, inflammatory cell infiltrates?
Hodgkin’s lymphoma
