Leukemia/Lymphoma

Question 1

What diagnosis should be given to a disease with greater than 20% blasts in bone marrow with blasts in peripheral blood, pancytopenia, variable white blood cell count, occasional Philadelphia chromosome?

Answer 1

ALL (acute lymphoblastic leukemia)

Question 2

Who usually gets ALL?

Answer 2

Children and older white males

Question 3

Which leukemic disease is treated with blood transfusions, radiation, chemotherapy, bone marrow transplant?

Answer 3

ALL

Question 4

Which disease is often idiopathic but can be linked to chemo, radiation, benzene exposure, or tobacco use?

Answer 4

AML (acute myeloid leukemia)

Question 5

Which disease presents with fever, infection, bleeding, bruising, gingival hyperplasia, ocular hemorrhages, DIC?

Answer 5

AML (acute myeloid leukemia)

Question 6

Which disease can be diagnosed based on pancytopenia, greater than 20% blasts in bone marrow and some in peripheral blood, leukocytosis, blasts on peripheral smear, Auer rod presence?

Answer 6

AML (acute myeloid leukemia)

Question 7

What disease presents with anemia, fatigue, fever, infection, mucosal bleeding, hepatosplenomegaly, lymphadenopathy, bone pain, testicular enlargement, gingival hyperplasia?

Answer 7

ALL (acute lymphoblastic leukemia)

Question 8

Which disease is treated with chemotherapy and BMT?

Answer 8

AML (acute myeloid leukemia)

Question 9

Who most often gets AML?

Answer 9

White males over age 65

Question 10

What are three possible complications of AML?

Answer 10

Hyperviscosity syndrome, tumor lysis syndrome, neutropenic fever

Question 11

Which symptoms qualify as neutropenic fever? How should it be treated?

Answer 11

Fever greater than 100.4 with neutropenia – treat with antibiotics empirically

Question 12

Which disease is 25% asymptomatic with some experiencing B symptoms, lymphadenopathy, hepatosplenomegaly, leukemia cutis, glomerulonephritis?

Answer 12

CLL (chronic lymphoblastic leukemia)

Question 13

Which disease can be diagnosed based on B cell lymphocytosis, smudge cells, anemia, thrombocytopenia, neutropenia, infiltrating leukemic cells in bone marrow?

Answer 13

CLL (chronic lymphoblastic leukemia)

Question 14

Which leukemic disease has no survival benefit for early treatment but most will eventually require chemo?

Answer 14

CLL (chronic lymphoblastic leukemia)

Question 15

What is a typical CLL patient?

Answer 15

Older males

Question 16

Name three complications of CLL

Answer 16

Immune defects, immunothrombocytopenic purpura, squamous cell carcinomas (skin cancer)

Question 17

Which leukemic disease has three phases: chronic, accelerated, and blast crisis?

Answer 17

CML (chronic myeloid leukemia)

Question 17

Which leukemic disease has 20 to 50% asymptomatic patients, fatigue, abdominal fullness, excessive sweating, weight loss, bleeding, bone pain, splenomegaly, gouty arthritis?

Answer 17

CML (chronic myeloid leukemia)

Question 18

Which disease has diagnostic criteria of elevated white blood count, Philadelphia chromosome, mostly neutrophils but can also be basophils and eosinophils, low number of blasts, myeloid hyperplasia?

Answer 18

CML (chronic myeloid leukemia)

Question 19

Which leukemic disease is treated with a tyrosine kinase inhibitor?

Answer 19

CML (chronic myeloid leukemia)

Question 20

What is the risk factor of CML?

Answer 20

Ionizing radiation

Question 21

Who typically gets CML?

Answer 21

Males around 50 to 60 years old

Question 22

What disease has B symptoms, painless lymphadenopathy, shortness of breath, pruritus, alcohol intolerance, decrease in performance status?

Answer 22

Hodgkin’s lymphoma

Question 23

Which diagnosis is suspected with painless lymphadenopathy, Reed Sternberg cells, inflammatory cell infiltrates?

Answer 23

Hodgkin’s lymphoma

Question 24

Which type of leukemia has a highly successful medicinal treatment available?

Answer 24

CML – Gleevec

Question 25

Which disease is usually treated with chemotherapy (ABVD) and radiation with 80% curability?

Answer 25

Hodgkin’s lymphoma

Question 26

Which disease has lymphadenopathy (of supraclavicular, cervical, and axillary node), B symptoms, hepatomegaly, recurrent infections, and potential anemia or thrombocytopenia with marrow involvement?

Answer 26

Non-Hodgkin’s lymphoma

Question 27

What diagnosis is indicated by painless lymphadenopathy, mediastinal adenopathy, possible elevated alkaline phosphate, possible elevated bilirubin?

Answer 27

Non-Hodgkin’s lymphoma

Question 28

Which disease has an uncurable indolent form, with aggressive form treatable with chemo and radiation?

Answer 28

Non-Hodgkin’s lymphoma

Question 29

Which is more common, Hodgkins or non-Hodgkin’s lymphoma?

Answer 29

Non-Hodgkin’s lymphoma

Question 30

Who is most at risk of contracting non-Hodgkin’s lymphoma?

Answer 30

HIV patients, immunosuppressed patients, history of EBV, H pylori, autoimmune disease

Question 31

Which disease has bone pain, M protein in urine or serum, clonal plasma cells in bone marrow, immune deficiency, anemia, kidney damage (Bence Jones proteins)?

Answer 31

Multiple myeloma

Question 32

What are the four most common symptoms of multiple myeloma?

Answer 32

Hypercalcemia, renal failure, anemia, lytic bone lesions

Question 33

Which diseases treated with autologous hematopoietic cell transplant, chemotherapy, and possibly radiation?

Answer 33

Multiple myeloma

Question 34

Which type of leukemia should not be treated with bone marrow transplant?

Answer 34

CLL

Question 35

Which type of platelet disorder should not be treated with platelet transfusion?

Answer 35

TTP