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Hemo 2 > Leukemia > Flashcards

Leukemia Flashcards

1
Q

What are some early terms associated with leukemia?

A

White, clone

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2
Q

Leukemia is a clonal proliferation of what kind of cells?

A

Lymphoid or meyloid

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3
Q

Clone is the cell population produced from what?

A

Single progenitor cell

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4
Q

True or false Leukemic styles are capable of proliferation and self renewal

A

True

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5
Q

Unregulated proliferating cells spell from where to what?

A

Bone marrow to peripheral blood

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6
Q

What areas can be affected by leukemia?

A

Spleen, lymph nodes, liver, etc.

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7
Q

As tissues and organs are infiltrated by these clones cells it causes tissue/organ what

A

Failure

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8
Q

How does the FAB classify leukemia?

A

Cell morphology, Seidel chemical results, clinical cafeteria, less than 30% of glass in the bone marrow

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9
Q

How does the WHO classify leukemia?

A

Morphology, Seidel chemistry, immunophenotype cd markers, genetics, clinical features, 20% of blasts in the bone marrow

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10
Q

What day with myelogenous leukemia’s have?

A

Granulocytic, erythrocytic megakaryocytic

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11
Q

What do the mono Citic leukemia’s having them?

A

Monocytes

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12
Q

What does lymphoid leukemia is having them?

A

T cells, B cells

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13
Q

What is acute leukemia?

A

Short duration with lots of amateurs in bone marrow and peripheral blood with increased white blood cells if untreated

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14
Q

Chronic leukemia is what?

A

Long duration with lots of matures in blood marrow in peripheral blood and low to Super increased white blood cells if untreated

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15
Q

Which is more common chronic or acute leukemia?

A

Acute

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16
Q

What is some evidence of acute leukemia?

A

Normal cidlik, normal chromic severe anemia, thrombocytopenia enlarged lymph nodes and spleen low white blood cell count and immunosuppression

17
Q

If untreated what is the prognosis of acute leukemia?

A

Several weeks to several months but ultimately fatal

18
Q

What does radiation therapy do?

A

Damages DNA resulting in cell death

19
Q

Drugs for leukemia work on what level?

A

Molecular

20
Q

Gleevec is what kind of drug

A

Tyronise kinase inhibitor

21
Q

Rituxab is what kind of drug

A

Acute lymphoblastic leukemia

22
Q

Chronic leukemia usually occurs when?

A

Older patients

23
Q

White blood cell count is usually high with what kind of leukemia?

A

Chronic

24
Q

Prognosis of chronic leukemia is what?

A

Months to years

25
Q

What are some factors related to the occurrence of leukemia?

A

Genetic and immuno logical factors, Occupational/environmental exposure, chemical and drug exposure, genetic abnormalities, viral agents

26
Q

What is a common sign of undiagnosed leukemia?

A

Leukocytosis or increased white blood cells

27
Q

How do we diagnose leukemia?

A

Morphology, cytochemistry, immunophenotyping, cytogenetics, molecular studies

28
Q

Flow cytomery is used to identify what?

A

Surface markers

29
Q

Cd 34s, TDT or surface markers for what?

A

Immatures

30
Q

CD33, 13, 14, 15 are surface markers for what?

A

Granulocytes/monocyte

31
Q

CD71 is a surface marker for?

A

Erythroid

32
Q

CD41, 42, 61 is a surface marker for?

A

Megakaryocytic

33
Q

Cd19, 20, 22 is a surface marker for?

A

B cells

34
Q

Cd2, Cd3 Cd4 and cd5 is a surface marker for?

A

T cells

35
Q

Cytogenetics is the study of what?

A

Chromosome structure and number and inheritance as they relate to a pathological state

36
Q

What is the role of chromosomes?

A

To transmit genetic material

37
Q

What is the normal karyotype?

A

22 pairs of autosomes one pair of sex chromosomes for a total of 46 chromosomes

38
Q

What are possible changes in chromosome?

A

Translocations and deletions inversions and additions

39
Q

P and q stand for what parts of a chromosome?

A

P stands for short arm, Q stands for a long arm

Hemo 2 (7 decks)

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