Leukemia Flashcards
Polycythemia dx
BM Bx: hypercellular & absent Fe stores
Splenomegaly
Essential Thrombocythemia Dx
Platelet count >450,000
BM Bx: megakaryocytes in clusters
MUST RULE OUT FE DEFICIENCY
CML Dx
philadelphia chromosome
Increased WBC: 100-200K
BCR/ABL gene
<5% blasts
polycythemia tx
phlebotomy
low dose ASA
high risk pts:
Hydroxyurea
Intereferon
Busulfan
Essential Thrombocythemia tx
low dose ASA
int-high risk:
hydroxyurea
INC RISK FOR thrombosis and hemorrhage
CML tx
allogenic SCT
dz control:
- tyrosine kinase inhibitors: inibs
- palliative: hydroxyurea, intereferon +/-cytarabine
AML dx
auer rod
pancytopenia w/circulating blasts
leukocytosis >200K
AML tx
chemo: 3+7 protocol
anthracycline + cytarabine
TOC: allogenic SCT
CLL dx
increased WBC with lymphocytosis
SMUDGE cells
CLL tx
bendamustine & rituximab
do you have enlarged spleen or LAD in aplastic anemia?
NO
PE of hairy cell leukemia
palpable splenomegaly
dx hairy cell leukemia
CBC: pancytopenia w/low monocytes
BM Bx: Hairy cells
CPx of PV
pruiritis after warm bath/shower
tinnitus
early satiety
erythromelalgia of hands and feet
facial plethora
excoriated skin
Mutation involved in both PV and essential thrombocythemia
JAK 2
overproduction of myeloid cells
CML
Which disorder can you have a blast cell crisis in?
CML
sx of blast crisis
fatigue
night sweats
low grade fever
pain from splenomegaly
biggest diff b/w AML and ALL
age:
AML: 60s
ALL: 3-7 y/old
AML sx
CNS manifestations
easy bruising/bleeding
frequent infections
fever
What is the MC lymphoid leukemia
CLL
aplastic anemia tx
allogenic SCT
or
immunosuppresion
