Let's get drunk

Question 1

What is the treatment for methanol?

Answer 1

ethanol

dialysis

Question 2

What are the first 2 enzymes in the alcohol metabolism?

Answer 2

1. alcohol dehydrogenase

2. aldehyde dehydrogenase

Question 3

What is the rate of alcohol elimination?

Answer 3

15mg/100ml/hour

Question 4

Why do women have lower alcohol tolerance?

Answer 4

• lower distribution volume
• higher subcutaneous fat
• less alcohol dehydrogenase

Question 5

WHat are the consequences of heavy drinking (on molecular level)?

Answer 5

1. Hepatic gluconeogenesis inhibition
2. Krebs cyle inhibition (aerobic -> anaerobic)
3. Impaired fatty acid oxidation

Question 6

What is Alcoholic Ketoacidosis associated with? What are the blood results like?

Answer 6

malnourished patients with chronic alcoholism

normal glucose
high ketones (beta-hydroxybutyrate)

Question 7

What effects does alcohol have on the CNS?

Answer 7

It is a CNS depressant

-it increases GABBA, which is a neurotransimitter inhibitor

Question 8

Why is water reabsorption by the kidney decreased following alcohol consumption?

Answer 8

Anti Diuretic Hormone (ADH) is inhibited

Question 9

Why does alcohol lead to increased heart rate?

Answer 9

Alcohol is a negative inotrope - it decreases the cardiac contractility
-it is compensated by increased heart rate