Lesson 2 - Enzyme Inhibition Flashcards
1
Q
What are the reversible inhibitors?
A
- Competitive inhibitors
- Noncompetitive inhibitors
- Uncompetitive inhibitors
2
Q
What is the irreversible inhibitor?
A
Irreversible (suicide) inhibitors
3
Q
What happens during competitive inhibition?
A
Inhibitor binds to active site of enzyme
Km ↑
Vmax =
4
Q
What happens during noncompetitive inhibition?
A
Inhibitor binds to allosteric site of enzyme
Km =
Vmax ↓
5
Q
What happens during uncompetitive inhibition?
A
Inhibitor binds to allosteric site of enzyme after enzyme-substrate complex is established
Km ↓
Vmax ↓
6
Q
What happens during irreversible (suicide) inhibition?
A
Inhibitor binds to active site of enzyme and forms covalent bonds rendering the enzyme useless
Km =
Vmax ↓
