Lesson 1 Flashcards
Who wrote a book on uroscopy in the 5th century BCE?
Hippocrates
Frederik Dekkers discovery in 1694 by boiling urine
Albuminuria
Who develop the methods of quantitating the microscopic sediments?
Thomas Addis
Introduced the concept of urinalysis in 1827
Richard Bright
A metabolic waste product produced in the liver
Urea
Organic substances of urine
Creatinine
Uric acid
Urea
Inorganic components of urine
Chloride
Sodium
Potassium
Urine composition
95% water
5% solutes
Decrease in urine output
Oliguria
Cessation of urine flow
Anuria
Increase in the nocturnal excretion of urine
Nocturia
Increase in daily urine volume
Polyuria
Decreased production of ADH leads to what?
Diabetes insipidus
Decreased insulin and increased glucose leads to what?
Diabetes mellitus
Fluid loss in both diseases is compensated by increased ingestion of water
Polydipsia
The recommended capacity of the urine container
50mL
Volume of the specimen needed for microscopic analysis
12mL
The most routinely used method of preservation
Refrigeration
What changes happen in an unpreserved urine? (Color)
Modified/darkened
Oxidation or reduction of metabolites
What changes happen in an unpreserved urine?
(Clarity)
Decreased
Bacterial growth and precipitated of amorphous material
What changes happen in an unpreserved urine?
(Odor)
Increased
Bacterial multiplication causing breakdown of urea to ammonia
What changes happen in an unpreserved urine?
(pH)
Increased
Breakdown of urea to ammonia by urease-producing bacteria
What changes happen in an unpreserved urine? (Glucose)
Decrease
Glycolysis and bacterial use
What changes happen in an unpreserved urine? (Ketones)
Decreased
Volatilization and bacterial metabolism
What changes happen in an unpreserved urine? (Bilirubin)
Decreased
Exposure to light/ photo oxidation to biliverdin
What changes happen in an unpreserved urine? (Urobilinogen)
Decreased
Oxidation to urobilin
What changes happen in an unpreserved urine? (Nitrite)
Increased
Multiplication of nitratre-reducing bacteria
What changes happen in an unpreserved urine? (Rbc and wbc casts)
Decreased disintegration in dilute alkaline urine
What changes happen in an unpreserved urine? (Bacteria)
Increased
Multiplication
What changes happen in an unpreserved urine? (Trichonomas)
Decreased
Loss of motility, death
It may be collected at any time
Random specimen
A type of preservatives that prevents bacterial growth and metabolism
Boric acid
Excellent sediment preservative
Formalin
A good preservative for drug analyses
Sodium fluoride
For routine screening, pregnancy test and orthostatic protein
First morning specimen
For quantitative chemical test
24 hour (or timed) specimen
For bacterial culture
Catheterized
For routine screening and bacterial culture
Midstream clean-catch
For bladder urine for bacterial culture
Suprapubic aspiration
For prostatic infection
Three-glass collection
Functional units of kidney
Nephrons
2 types of nephrons
Cortical- responsible for removal of waste products and reabsorption of nutrients.
Juxtamedullary- for the concentration of the urine
Renal functions:
Renal blood flow
Glomerular filtration
Tubular reabsorption
Tubular secretion
This is where the blood enters the capillaries of the nephron
Afferent arteriole
This is where the major exchanges of of water and salts takes place between the blood and the medullary interstitium
Vasa recta
Hydrostatic pressure and osmotic gradient occur
Renal blood flow
Physical examination of urine:
Color, clarity, specific gravity, odor
Normal urine color
Yellow
Pigment that causes yellow color in urine
Urochrome
Dark yellow or amber urine
Presence of bilirubin
Yellow- green color
Presence of biliverdin
Red and cloudy
Presence of rbc
Red and clear
Presence of myoglobin and hemoglobin
Brown or black
Melanoma
Blue or gree
Pseudomonas infection
No visible particulates
Clear
Few particulates
Hazy
Many particulates
Cloudy
Print cannot be seen through urine
Turbid
Precipitate or be clotted
Milky
Presence of squamous epithelial cells and mucus
Nonpathologic turbidity
Presence of rbc, wbc, and bacteria in urine
Pathologic turbidity
Determines the concentration of dissolved particles in a specimen by measuring refractive index
Refractometer
It consist of weighted float attached to a scale that has been calibrated in terms of urine specific gravity
Urinometry
What is the odor of a freshly voided urine
Aromatic
Cause of ammonia-like odor
Bacterial decomposition, UTI
Cause of fruity sweet odor
Ketones
Cause of maple syrup odor
Maple syrup urine disease
Cause of mousy odor
Phenylketonuria
Cause of rancid odor
Tyrosinemia
Cause of sweaty feet odor
Isovaleric acidemia
Cause of cabbage odor
Methionine malabsorption
Cause of bleach odor
Contamination