Lesions to hypothalamus

Question 1

Neuroendocrine regulation (oxytocin and ADH)

Answer 1

-results in abnormal endocrine production resulting in multi system malfunction
>diabetes insipidus
>cushings (hyperadrenocorticism)
**affected by foreign bodies (fox tails, quils), tumors,

Question 2

Regulation center for ANS

Answer 2

-results in organ dysfunction, inability to maintain blood pressure, and inability to thermoregulate

Question 3

Coordination and production of defensive behaviour

Answer 3

*because hypothalamus is part of limbic system
-results in increased aggression (rage behaviour), increased fear and stargazing behaviour
Ex. rabies virus

Question 4

Thermoregulation

Answer 4

-various regions: includes heat loss center (hypothermia), and heat retention center (hyperthermic)
-Ex. animal seeking out warmer or colder areas
>hypertrophy of thyroid gland which will change the internal set point of what you consider cold vs hot.

Question 5

Osmoregulation and water intake

Answer 5

-results in abnormal water consumption (polydipsia or adypsia)

Question 6

Food intake and metabolism

Answer 6

-abnormal feeding behaviours (polyphagia or aphagia)

Question 7

Circadian rhythmicity (input form environment regarding day to day)

Answer 7

-in animals, we do not appreciate abnormalities in sleep-wake cycles BUT they are reported in humans

Question 8

Masses occupying the space in hypothalamus

Answer 8

-can result in abnormal vision (close proximity to optic chiasm) OR result in abnormal consciousness (close proximity to thalamus and reticular formation in the brainstem)

Question 9

Fevers

Answer 9

-abnormal increase in normal body temperature even though animal is not actually cold

Question 10

General anesthesia &hypothalamus

Answer 10

-alter the level of consciousness of the animals which means they will likely effect the areas of the hypothalamus
>could be reason for animals getting cold while under anesthesia