Leprosy

Question 1

It is an obligate intracellular bacillus that is confined and reside macrophages of humans, armadillos and sphagnum moss. (Harrison pp 1122)

Answer 1

Mycobacterium leprae

Question 2

It has the highest disease prevalences and the other has the most cases, respectively. (Harrison pp 1123)

Answer 2

Africa and Asia

Question 3

Leprosy is associated with what following. (Harrison pp 1123)

Answer 3

Poverty

Rural

Question 4

When is the peak onset of Leprosy? (Harrison pp 1123)

Answer 4

2nd to 3rd decades of Life

Question 5

What are the transmission route of Leprosy? (Harrison pp 1123)

Answer 5

Infected soil (most common)
Nasal droplet
Insect vectors

Question 6

It is one or few sharpley defined annular asymmetric macules or plaques with a tendency toward central clearing and elevated borders. And also have positive Lepromin skin test.

Answer 6

Tuberculoid (TT, BT) Leprosy

Question 7

It is symmetric andnporrly marginated, multiple infiltrated nodules and plaques or diffuse infiltration, xanthoma like or dermatofibroma papules, leonine facies and eyebrows alopecia. And has acid fast bacilli of 4-6+. (Harrison pp 1123)

Answer 7

Lepromatous Leprosy

Question 8

It is the most common form of disease encountered in India and Africa but virtually absent in Southeast Asia. It is also devoid of normal skin organs (eg sweat glands and hair follicles). (Harrison pp 1124)

Answer 8

Tuberculoid Leprosy

Question 9

What are the commonly affected area in Tuberculoid Leprosy? (Harrison pp 1124)

Answer 9

Ulnar
Posterior auricular
Peroneal
Posterior tibial nerves

Question 10

Leonine Facies. And its late presentation inlude loss of eyebrows ofthe lateral margins.
Its has a Acral, distal, symmetric peripheral neuropathy and tendency toward symmetric nerve trunk enlargement (Harrisons pp 1124)

Answer 10

Lepromatous Leprosy

Question 11

It is a type of reactions occur in almost half of the patients with borderline forms of leprosy but not in patients with pure lepromatous disease. The most dramatic manifestations is foot drop. . (Harrison pp 1125)

Answer 11

Type 1 Lepra Reactions

Question 12

What are the histologically lesions that are characterized in Lucio’s phenomenom? (Harrison pp 1125)

Answer 12

Ischemic Necrosis of the epidermis and Superficial dermis
Heavy parasitism
Endothelial proliferation
thrombus formation

Question 13

When would be the right time for Tendon transfer to restore hand function? (Harrison pp1125)

Answer 13

6 months after the initiation of antimicrobial therapy and the conclusion of episodes of acute neuritis.

Question 14

It is the only drug that is bactericidal in Leprosy (Harrison pp 1126)

Answer 14

Rifampin

Question 15

It is the first antimicrobial agents and the mainstay therapy for leprosy. (Harrison pp1126)

Answer 15

Dapsone

Question 16

It includes high fever, anemia, exfoliative detmatitis and a mononucleosis type of blood pressure. (Harrison pp 1126)

Answer 16

Sulfone Syndrome

Question 17

It is associated with red blavk skin discoloration (Harrison pp 1126)

Answer 17

Clofazimine