Leprosy Flashcards
Leprosy was founded by who in what year
Founded by gerhard Hansen in 1873
What is the microbial physiology of micro bacterium leprae Bacillius
Leprae is an acid fast bacilli
Non sporing non motile aerobic rod shaped Bacillius
It’s is obligately Intracellular
When is smear tissue stains, leprae Bacillius stays singly or in compact called
Globi
How is leprosy contacted
Leprosy is transferred from person to person in close asscociation by inhaling their infected aerosols
Leprosy easily affects what age range
Children
Anoda name for leprosy is
Hansen disease
Generation time for leprae is
12-13days
Incubation time for leprosy is
2-7yrs
Can leprosy affects a child in the womb nd why
Leprosy cannot cross the placenta barrier
What is the pathogenesis of leprosy
Leprosy is a nerve loving bacteria
It’s attacks nervous system by eating away at the Schwan cells
Leprosy is more susceptible in what weather condition
In cold environment
Stays in the pns
Leprosy that affects an immunocompetent individual clinically manifests as
Tuberculoid leprosy
Which of these is not a clinical presentation of leprosy
Borderline tuberculoid leprosy
Borderline leprosy
Lepratomous leprosy
Borderline borderline leprosy
Tuberculoid leprosy
Borderline leprosy
Mention the clinical presentation of leprosy
Leprosy that affects immunocompromised individual clinically manifest as
Lepratomous leprosy
Leprosy which presents with skin lesions is what type of
Tuberculoid leprosy
Leprae Bacillius involving only one peripheral nerve and causes skin blemish is what type of leprosy
Tuberculoid leprosy
Leprosy manifesting with skin nodules, lesions to multiple nerve nd damage to other organs is what type of leprosy
Lepratomous leprosy
Neural manifestation of Tuberculoid leprosy
Pain
Tingling
Muscle weakness
Paralysis
Dermal manifestation of Tuberculoid leprosy
Loss of hair
Loss of sweating
Thickening of nerve
Clinical manifestation of Lepratomous leprosy
Nodules in the body nd other organ systems
Presence of nodules
Chronic leg edema
Test to check for leprosy include
Lepromin test
Histamine test
Pilocarpine test
What is the mechanism of action of a lepromin test
It is an autoclaved suspension of tissue gotten from an infected armadillos
We inject it Intradermally and get either a fernandez (early) or mitsuda (late) reaction
A mitsuda reaction is
A late reaction to a lepromin test for leprosy
A Fernandez reaction is
An early reaction to a Lepromin test
Intermediate clinical manifestation of leprosy include
Borderline borderline leprosy
Borderline Lepratomous
Borderline tuberculoid
Multibacilliary multidrug therapy are drugs that shows
That show a positive skin smear test and a negative lepromin test
Drugs for leprosy include
Dapsone
Clofizamine
Rifampicin
Multibacilliary therapy checks for what type for bacteria
Lepratomous leprosy
Borderline Lepratomous leprosy
Borderline borderline leprosy
Paucibacilliary therapy checks for what type for bacteria
Tuberculoid leprosy
Borderline tuberculoid leprosy
Paucibacilliary multidrug therapy presents with
Presents with negative skin smear and positive lepromin test
