Leishmania Flashcards
What is the insect vector for leishmania?
Sandfly
Inside the human host, which cells do the parasites replicatewithin?
Macrophages
What are the two forms of leishmania and how are they different?
Promastigotes – found in the sandfly – they have a flagellum (which they move towards) and they are motile
Amastigotes – found within humans/other vertebrate hosts – they have resorbed their flagellum and are no longer motile – found in macrophages
Where, across the world, are sandflies found?
Warm parts of the world – Southern Europe, Asia, Africa, Central and South America, Australia
How is transmission of leishmania in Europe changing?
It is spreading northwards
Which gender of sandflies takes blood meals?
Females – need blood to provide nutrition for eggs
What are the four major forms of leishmaniasis?
Visceral Leishmaniasis Cutaneous Leishmaniasis Diffuse Cutaneous Leishmaniasis Mucocutaneous Leishmaniasis
What is another name for visceral leishmaniasis?
Kala Azar (black fever)
What are the features of visceral leishmaniasis?
Irregular fever
Weight loss
Enlarged liver and spleen
Anaemia
What are some risk factors for visceral leishmaniasis?
Malnutrition
Immunosuppression (e.g. because of drugs)
HIV
Which type of leishmania causes the majority of cases of visceral leishmaniasis in Ethiopia?
L. donovani
How is visceral leishmaniasis diagnosed?
Visualisation of the amastigote parasite my microscopic examination of aspirates
Antibody detection
What are the treatment options for visceral leishmaniasis?
Sodium stibogluconate or meglumin antimoniate
Liposomal amphotericin B
What other clinical manifestation of leishmania can occur during or after treatment for visceral leishmaniasis?
Post Kala-azar Dermal Leishmaniasis (PKDL)
Describe the features of local cutaneous leishmaniasis.
Heals spontaneously
Immunity from reinfection
NOTE: it can still leave disfiguring scars
