lectures 24-26 Flashcards
1
Q
How are caspases typically activated?
A
cleavage
2
Q
How does XIAP inhibit apoptosis?
A
Binds to caspase-9 and caspase-3 to inhibit their activity
3
Q
How does Bcl-2 inhibit apoptosis?
A
Inhibits bax oligomerization and cytochrome c release
4
Q
True or false. Smac/Diablo is an anti-apoptotic protein.
A
False; it’s a pro-apoptotic protein
5
Q
How does Caspase 3 cause DNA fragmentation?
A
Caspase-3 cleaves ICAD
