Lectures 1-3 (Properties of Biological Molecules) Flashcards

1
Q

Covalent bonds are [stronger/weaker] than noncovalent interactions.

A

Stronger

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2
Q

Covalent bond length is [shorter/longer] than noncovalent interactions.

A

Shorter

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3
Q

Describe the connectivity of covalent bonds.

A

Share electrons

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4
Q

Describe the connevtivity of noncovalent interactions.

A

Attraction only

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5
Q

Bond between monomers of proteins.

A

Peptide

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6
Q

Bond between monormers of carbohydrates.

A

Glycosidic

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7
Q

Bond between monomers of lipids.

A

Ester

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8
Q

Bond between monomers of nucleic acids.

A

Phosphodiester

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9
Q

How is bond strength measured?

A

In terms of energy needed to break bonds (i.e. can be dependent on bond length)

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10
Q

Examples of charge-charge interaction.

A

Ionic bonds (i.e. NaCl), salt bridges (i.e. interaction between 2 AA in a protein)

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11
Q

In a vacuum, how would you measure how attractive two ions are to each other?

A

Coulomb’s Law

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12
Q

Equation for Coulomb’s Law

A

Where F = Force between ions in Newtons; q = Ion charges in Coulombs, k = 8.85 x 10-12 C2/J*m; r = distance between nuclei

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13
Q

In a biological environment, what must be accounted for when measuring how attractive two ions are to each other?

A

Relative permittvity

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14
Q

Equation for measuring that attraction of two ions in a biological environment.

A

Where D = Dielectric constant

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15
Q

Equation for measuring energy of interactions.

A
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16
Q

Qualitative interpretation of F>0 (i.e. in terms of Coulomb’s Law).

A

Ions are repulsed

17
Q

Qualitative interpretation of F<0 (i.e. in terms of Coulomd’s Law).

A

Ions attract

18
Q

Qualitative interpretation of E<0 (i.e. in terms of energy of interaction equation).

A

Attraction

19
Q

Qualitative interpretation of E>0 (i.e. in terms of energy of interaction equation).

A

Not considered

20
Q

Nature of interaction of hydrogen bonds.

A

Share a hydrogen atom/proton.

21
Q

Type of bonds with the shortest bond length.

A

Covalent bonds

22
Q

Type of bonds with the strongest bond energy.

A

Covalent bonds

23
Q

Type of bonds with the lowest bond energies.

A

Van der Waals interactions

24
Q

What is the optimal phase state for H-bonding of water?

A

Solid (i.e low temperature, low motion/energy)

25
Q

At what point can water no longer form H-bonds?

A

When it is a gas

26
Q

List waters four unqiue properties.

A

Solid density < liquid density, changing temperature is difficult, strong surface tension, and universal solvent.

27
Q

Amount of heat energy needed to change the temperature of 1 g of a given substrate by ±1 °C.

A

Specific heat capacity (i.e. why the ocean does not freeze)

28
Q

The amount to energy needed to change 1 g of a given substance from a liquid to a gas.

A

Heat of vaporization (i.e. why sweating removes body heat)

29
Q

Property of water that permits surface tension.

A

Cohesion of water

30
Q

Properties of water that permits capillary action.

A

Both adhesion and cohesion

31
Q

The breaking/making of chemical bonds.

A

Chemical reactions

32
Q

Noncovalent interactions - Energy is [used/released] to break bonds; energy is [used/released] when bonds are formed

A

Used; Released

33
Q

Covalent interactions - Energy is [used/released] when bonds are broken, energy is [used/released] when bonds are formed.

A

Released; Used

34
Q

True/False: Equilibrium means equal concentrations.

A

False

35
Q

Dissociation constant (Ka) equation.

A
36
Q

Equation for pKa.

A
37
Q

The larger the Ka the [weaker/stronger] the acid.

A

Stronger

38
Q

The larger the pKa the [weaker/stronger] the acid.

A

Weaker

39
Q

[Weaker/Stronger] acids have a larger energy of interaction than its counterpart.

A

Weaker