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Mitochondria > Lecture9 > Flashcards

Lecture9 Flashcards

1
Q

MTS - is?

A

Mitochondrial targeting signal

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2
Q

for an approach to target specific mutations, we can use FOKL which is a

A

nuclease

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3
Q

What are the Challenges associated with live-cell microscopy?

A

• Bleaching
(fading of the fluorescent protein)
• Phototoxicity
(too much light is toxic for cells)

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4
Q

What is the Mitochondrial Fusion?

A

2 Mitochondria fuse to form 1 mitochondrion

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5
Q

What is the Mitochondrial Fission?

A

1 Mitochondrion divides into 2 daughter mitochondria

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6
Q

mgm1 is highly conserved in mammals called…

A

opa1

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7
Q

What does Nebenkern mean?

A

Aggregated mitochondria that appear close to the nucleus during spermatogenesis

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8
Q

FZO (Fuzzy onion) is Discovered in…

A

Drosophila

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9
Q

S. cerevisiae—> FZO1

Mammals —>

A

MFN1/MFN2

Mitofusins

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10
Q

mgm1 is localized in …

FZo1 localized in …

A

IM and a big part of it is exposed into IMS, FZO1 OM

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11
Q

What do you know about DNM1?

A
  • Isolated in a visual yeast screen

* First component of the mitochondrial fission machinery

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12
Q

to which family do DNM1, FZO1, and mgm1 belong?

A

Dynamin like proteins

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13
Q

For fussion we have:

A

Fzo1 / Mfn1, Mfn2

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14
Q

For fission we have :

A

Dnm1/ Drp1

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15
Q

What its cycloheximide function?

A

is translation inhibitor and it inhibit translation in cytosol

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16
Q

Mfn1/2 can dimerize in trans via their cytoplasmic… domains

A

coiledcoil

17
Q

When the GTPase domain of Mitofusins is mutated, in Which stage mitochondrial fusion is trapped?

A

at the tethering stage

18
Q

Mutation of the GTPase domain in Mitofusin results in
aggregation of mitochondria, mitochondria are tethered and a
gap can be observed between mitochondria
What do you think?

A

yes

19
Q

Mgm1/Opa1 are imported for fusion of…

A

IM

20
Q

… and … are required for mitochondrial fusion

A

GTP and Membrane potential

21
Q

Fzo1 =

A

Mitofusins

22
Q

Purified Dnm1/Drp1 can form oligomeric rings.

True or false

A

True

23
Q

High mitochondrial activity leads to high….

A

ROS

24
Q

Neurons have a high energy demand, especially at…

A

synapses

25
Q

Neurons crucially depend on mitochondrial transport

A

yes

26
Q

…. interacts with Kinesin

A

Milton interacts with Kinesin

27
Q

Neither Milton nor KHC has a mitochondrial targeting signal or a
transmembrane segment

A

True

28
Q

Milton interacts with…, a mitochondrial protein

A

Miro, a mitochondrial protein

29
Q

Ca2+ inhibits mitochondrial motility

A

yes

30
Q

Calcimycin leads to a rise in intracellular Ca2+ content

A

true

Mitochondria (9 decks)

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