Lecture Mod 1 Flashcards

Endocrine, Lymphatic and Immune

1
Q

Direct Communication

A

Gap junctions allow for small molecule and ion transfer directly between cells. Small solutes and ions go directly between cells.
found between cardiac muscles and intercalated discs. Helps coordinated heart beats

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2
Q

Autocrine Communication

A

A signaling molecule affects the same type of cell that is secreted in the same tissue. Close range; self-stimulation.

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3
Q

Endocrine Communication

A

A signaling molecule is secreted into the blood stream and acts on a distant target/organ.

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4
Q

Paracrine Communication

A

A signaling molecule affects a cell type differently from one secreted in the same tissue. Short distance.

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5
Q

Synaptic Communication

A

A signaling molecule stimulates a cell at a junction between a neuron and its target. Specific to nervous system.

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6
Q

Calcitonin: philic or phobic

A

Hyodrophilic

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7
Q

Calcitriol: philic or phobic

A

Hydrophobic

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8
Q

Cortisol: philic or phobic

A

Hydrophobic

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9
Q

Epinephrine: philic or phobic

A

Hydrophilic

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10
Q

Estrogen: philic or phobic

A

Hydrophobic

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11
Q

Prolactin: philic or phobic

A

Hydrophilic

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12
Q

Thyroid hormone: philic or phobic

A

Hydrophobic

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13
Q

TSH: philic or phobic

A

Hydrophilic

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14
Q

Hormone produced by Glomerulosa

A

Aldosterone

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15
Q

Hormones produced by reticularis

A

Androgens (sex steroids)

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16
Q

Hormones produced by fasciculata

A

Cortisol (glucocorticoids)

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17
Q

Hormones produced by medulla

A

Epi and norepi

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18
Q

The most important hormone in calcium homeostasis

A

PTH

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19
Q

MHC 1: Extra or intra

A

Intra

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20
Q

MHC II: Extra or intra

A

Extra

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21
Q

Transcription factors means that these hormones have a ______ effect

A

Larger

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22
Q

Intracellular hormone receptors have to be:

A

Hydrophobic

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23
Q

Extracellular hormone receptors have to be:

A

Hydrophilic

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24
Q

Transcription factors

A

Change gene expression

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25
Q

G-protein coupled receptors and cAMP: LOOK AT WORKSHEET

A

Hydrophilic hormone binds to receptor. G protein is activated. Activation of adenylyl cyclase. Conversion of ATP to cyclic CMP (second messenger). Activation of protein kinases. Initiation of phosphorylation cascade.

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26
Q

Upregulation

A

Smaller amount of hormone, increases # of receptors

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27
Q

Downregulation

A

High levels of circulating hormones, decrease the # of hormones.

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28
Q

Permissive effect

A

Presents of one hormone enables another hormone to act.

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29
Q

Example of permissive effect of a hormone

A

Estrogen priming: uterine cells must be exposed to estrogen before progesterone can have an affect.

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30
Q

Synergistic effect

A

Two hormones together have an amplified response

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31
Q

Example of a synergistic effect

A

Thyroid hormone and the sympathetic nervous system

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32
Q

Antagonistic effect

A

Two hormones have opposing effects

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33
Q

Example of antagonistic effect

A

Insulin and glucagon

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34
Q

Humoral stimuli

A

Something in blood causes hormone release.

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35
Q

Example of humoral stimuli

A

High level of glucose causes the release of insulin

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36
Q

Hormonal stimuli

A

Hormone causes the release of another hormone

37
Q

Example of hormonal stimuli

A

Growth hormone-releasing hormone causes the release of growth hormone

38
Q

Neural stimuli

A

Nervous system causes the release of hormones

39
Q

Example of neural stimuli

A

Release of epinephrine

40
Q

TRH releases:

41
Q

Corticotropin-releasing hormone releases:

42
Q

What is stored in the posterior pituitary?

A

Oxytocin and ADH

43
Q

Diabetes inspidus

A

Increase in urination

44
Q

Hormones produced by the hypothalamus are: Hydro____

45
Q

Alarm phase of the general adaptation syndrome: dominant hormone

A

Immediate stress response. Dominate hormone is epinephrine.

46
Q

Resistance phase of the general adaptation syndrome

A

Glucocorticoids are the dominant hormones

47
Q

Alpha cells in pancreas produce:

48
Q

Beta cells in pancreas produce:

49
Q

Delta cells in the pancreas produce:

A

Somatostatin

50
Q

Glycogenolysis

A

Increase blood glucose by glucagon

51
Q

Gluconeogenesis

A

Synthesis of blood glucose

52
Q

Polyuria

A

Increase in urination

53
Q

Polydipsia

A

Increase in thirst

54
Q

Polyphagia

A

Increase in hunger

55
Q

Cytotoxic t-cells are CD__ +

56
Q

Helper t-cells are CD__+

57
Q

Where are lymphatic capillaries not present?

A

Central nervous system, cornea, etc…

58
Q

What is the flow of lymph from the lymphatic capillaries to the subclavian veins?

A

Lymphatic capillarieslarger lymphatic vesselslymph nodeslymphatic trunkssubclavian veins

59
Q

Which part of the body drains into the thoracic duct?

A

Left side and lower body

60
Q

Which part of the body drains into the R lymphatic duct?

A

Right upper body

61
Q

Where do b cells mature?

A

Red bone marrow

62
Q

Where do t cells mature?

63
Q

Antigen-presenting cells:

A

B cells, dendritic cells and macrophages

64
Q

Most common WBC

A

Neutrophils

65
Q

Cytokine

A

Short-distance signaling molecules

66
Q

Chemokines

A

Attract cells over a long distance

67
Q

Function of interferons

A

Secreted by virally infected cells. Other cells in this area can produce antiviral proteins that inhibit viral replication

68
Q

In complement activation, what happens after C1 binds to the antibody?

A

C1 is activated

69
Q

What happens after C1 is activated?

A

Active C1 activates c2 and c4

70
Q

What does c2 activate?

A

C2a and C2b

71
Q

What does C4 activate?

A

C4a and C4b

72
Q

What does C2b and C4b activate?

A

C3 convertase

73
Q

What does C3 convertase activate?

74
Q

What does C3 activate?

A

C3a and C3b

75
Q

Effects of complement activation. C3a

A

C3a attracts phagocytes to the area.

76
Q

Effects of complement activation. C3b

A

C3b binds the surface of a pathogen, opsonization and activates C5-9, forming a membrane attack complex.

77
Q

Pyrogen

A

Causes a fever

78
Q

Which t cell is part of a MHC 1?

79
Q

Which t cell is a part of MHC II?

80
Q

MHC___, ____ t-cell, ______ destroyed

A

II, helper, indirectly destroyed

81
Q

MHC___, ____ t-cell, ______ destroyed

A

I, cytotoxic, directly

82
Q

T-cell dependent activation of b cells:

A

Stronger, longer-lasting immune response.

83
Q

T-cell independent activation of b cells:

A

Faster, weaker response

84
Q

Constant segments of an antibody determines which?

A

Class of antibody

85
Q

Variable segments of antibodies:

A

Determines specificity

86
Q

Active natural immunity

A

Occurs when a person is exposed to a pathogen and the immune system responds by producing antibodies and memory cells

87
Q

Active artificial immunity

A

Occurs when a person is exposed to an antigen through vaccination, stimulating an immune response without causing disease

88
Q

Passive natural immunity

A

Occurs when a mother passes antibodies to her baby naturally, without medical intervention

89
Q

Passive artificial immunity

A

Occurs when a person receives antibodies through medical intervention