Lecture Mod 1 Flashcards
Endocrine, Lymphatic and Immune
Direct Communication
Gap junctions allow for small molecule and ion transfer directly between cells. Small solutes and ions go directly between cells.
found between cardiac muscles and intercalated discs. Helps coordinated heart beats
Autocrine Communication
A signaling molecule affects the same type of cell that is secreted in the same tissue. Close range; self-stimulation.
Endocrine Communication
A signaling molecule is secreted into the blood stream and acts on a distant target/organ.
Paracrine Communication
A signaling molecule affects a cell type differently from one secreted in the same tissue. Short distance.
Synaptic Communication
A signaling molecule stimulates a cell at a junction between a neuron and its target. Specific to nervous system.
Calcitonin: philic or phobic
Hyodrophilic
Calcitriol: philic or phobic
Hydrophobic
Cortisol: philic or phobic
Hydrophobic
Epinephrine: philic or phobic
Hydrophilic
Estrogen: philic or phobic
Hydrophobic
Prolactin: philic or phobic
Hydrophilic
Thyroid hormone: philic or phobic
Hydrophobic
TSH: philic or phobic
Hydrophilic
Hormone produced by Glomerulosa
Aldosterone
Hormones produced by reticularis
Androgens (sex steroids)
Hormones produced by fasciculata
Cortisol (glucocorticoids)
Hormones produced by medulla
Epi and norepi
The most important hormone in calcium homeostasis
PTH
MHC 1: Extra or intra
Intra
MHC II: Extra or intra
Extra
Transcription factors means that these hormones have a ______ effect
Larger
Intracellular hormone receptors have to be:
Hydrophobic
Extracellular hormone receptors have to be:
Hydrophilic
Transcription factors
Change gene expression
G-protein coupled receptors and cAMP: LOOK AT WORKSHEET
Hydrophilic hormone binds to receptor. G protein is activated. Activation of adenylyl cyclase. Conversion of ATP to cyclic CMP (second messenger). Activation of protein kinases. Initiation of phosphorylation cascade.
Upregulation
Smaller amount of hormone, increases # of receptors
Downregulation
High levels of circulating hormones, decrease the # of hormones.
Permissive effect
Presents of one hormone enables another hormone to act.
Example of permissive effect of a hormone
Estrogen priming: uterine cells must be exposed to estrogen before progesterone can have an affect.
Synergistic effect
Two hormones together have an amplified response
Example of a synergistic effect
Thyroid hormone and the sympathetic nervous system
Antagonistic effect
Two hormones have opposing effects
Example of antagonistic effect
Insulin and glucagon
Humoral stimuli
Something in blood causes hormone release.
Example of humoral stimuli
High level of glucose causes the release of insulin
Hormonal stimuli
Hormone causes the release of another hormone
Example of hormonal stimuli
Growth hormone-releasing hormone causes the release of growth hormone
Neural stimuli
Nervous system causes the release of hormones
Example of neural stimuli
Release of epinephrine
TRH releases:
TSH
Corticotropin-releasing hormone releases:
ACTH
What is stored in the posterior pituitary?
Oxytocin and ADH
Diabetes inspidus
Increase in urination
Hormones produced by the hypothalamus are: Hydro____
Philic
Alarm phase of the general adaptation syndrome: dominant hormone
Immediate stress response. Dominate hormone is epinephrine.
Resistance phase of the general adaptation syndrome
Glucocorticoids are the dominant hormones
Alpha cells in pancreas produce:
Glucagon
Beta cells in pancreas produce:
Insulin
Delta cells in the pancreas produce:
Somatostatin
Glycogenolysis
Increase blood glucose by glucagon
Gluconeogenesis
Synthesis of blood glucose
Polyuria
Increase in urination
Polydipsia
Increase in thirst
Polyphagia
Increase in hunger
Cytotoxic t-cells are CD__ +
CD8
Helper t-cells are CD__+
CD4
Where are lymphatic capillaries not present?
Central nervous system, cornea, etc…
What is the flow of lymph from the lymphatic capillaries to the subclavian veins?
Lymphatic capillarieslarger lymphatic vesselslymph nodeslymphatic trunkssubclavian veins
Which part of the body drains into the thoracic duct?
Left side and lower body
Which part of the body drains into the R lymphatic duct?
Right upper body
Where do b cells mature?
Red bone marrow
Where do t cells mature?
Thymus
Antigen-presenting cells:
B cells, dendritic cells and macrophages
Most common WBC
Neutrophils
Cytokine
Short-distance signaling molecules
Chemokines
Attract cells over a long distance
Function of interferons
Secreted by virally infected cells. Other cells in this area can produce antiviral proteins that inhibit viral replication
In complement activation, what happens after C1 binds to the antibody?
C1 is activated
What happens after C1 is activated?
Active C1 activates c2 and c4
What does c2 activate?
C2a and C2b
What does C4 activate?
C4a and C4b
What does C2b and C4b activate?
C3 convertase
What does C3 convertase activate?
C3
What does C3 activate?
C3a and C3b
Effects of complement activation. C3a
C3a attracts phagocytes to the area.
Effects of complement activation. C3b
C3b binds the surface of a pathogen, opsonization and activates C5-9, forming a membrane attack complex.
Pyrogen
Causes a fever
Which t cell is part of a MHC 1?
Cytotoxic
Which t cell is a part of MHC II?
Helper
MHC___, ____ t-cell, ______ destroyed
II, helper, indirectly destroyed
MHC___, ____ t-cell, ______ destroyed
I, cytotoxic, directly
T-cell dependent activation of b cells:
Stronger, longer-lasting immune response.
T-cell independent activation of b cells:
Faster, weaker response
Constant segments of an antibody determines which?
Class of antibody
Variable segments of antibodies:
Determines specificity
Active natural immunity
Occurs when a person is exposed to a pathogen and the immune system responds by producing antibodies and memory cells
Active artificial immunity
Occurs when a person is exposed to an antigen through vaccination, stimulating an immune response without causing disease
Passive natural immunity
Occurs when a mother passes antibodies to her baby naturally, without medical intervention
Passive artificial immunity
Occurs when a person receives antibodies through medical intervention