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Hema 2 > Lecture | Midterms Review > Flashcards

Lecture | Midterms Review Flashcards

1
Q

Bleeding time is used to evaluate the activity of:

A. Platelets
B. Prothrombin
C. Factor xiii
D. Labile factor

A

Platelets

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2
Q

Which of the following test results is normal in a patient with classic Von willebrand’s disease?

APTT
Bleeding time
Platelet count
VWF level

A

Platelet count

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3
Q

No bleeding is observed in a deficiency of which of the following factors?

II
XII
IX
VIII

A

XII

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4
Q

Hemolytic uremic syndrome is associated with:

Fever and thrombocytosis
Granulocytosis
E. coli
Leukocytosis

A

E. coli

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5
Q

Coagulation factors affected by coumarin drugs:

VIII, IX, and X
I, II, V, and VII
II, VII, IX, and X
II, V, and VII

A

II, VII, IX, and X

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6
Q

Thrombotic thrombocytopenic purpura is characterized by:

Prolonged pt
Increased platelet aggregation
Thrombocytosis
Prolonged aptt

A

Increased platelet aggregation

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7
Q

A protein that plays a vital role in both coagulation and platelet aggregation?

I
Xl
Vlll
IX

A

I

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8
Q

The defect characterizing Gray’s syndrome:

Platelet adhesion
Dense granule
Alpha granule
Coagulation defect

A

Alpha granule

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9
Q

Factor XIII is caused by which factor?

Ila
Va
Xa
Fibrinogen

A

Ila

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10
Q

Factor V is a cofactor to factor X to activate factor Il.
T/F

A

True

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11
Q

What clotting factors are inhibited by proteins?

V and X
V and VIII
VIl and IX
VIII and X

A

V and VIII

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12
Q

What is the second phase of secondary homeostasis?

Contact phase
Activation of factor vii
Activation of factor x
Formation of fibrin cot

A

Activation of factor x

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13
Q

Several hours after birth, a baby develops petechiae and a hemorrhagic diathesis. Platelet count is 8,000/ul. What is likely the explanation?

Drug-induced thrombocytopenia
Secondary thrombocytopenia
Isoimmune neonatal thrombocytopenia
Neonatal DIC

A

Isoimmune neonatal thrombocytopenia

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14
Q

When performing platelet aggregation studies, which is most likely associated with Bernard soulier’s syndrome?

Decreased with ADP
Normal to epinephrine, decreased to ristocetin
Normal to epinephrine and ristocetin, decreased with collagen
Normal to collagen, ADP, and risfaceton

A

Normal to epinephrine, decreased to ristocetin

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15
Q

Which of the following is a characteristic of acute idiopathic thrombocytopenic purpura?

Insidious onset
Spontaneous remission within a few weeks
Predominantly seen in adults
Nonimmune platelet destruction

A

Spontaneous remission within a few weeks

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16
Q

Factor xiii is a serine protease

T/f

A

False

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17
Q

Which of the following inhibitors inhibit factor IIa?

Protein C
Antithrombin III
Both
Neither

A

Both

18
Q

Which of the following is correct regarding acquired thrombotic thrombocytopenic purpura?

Autoimmune disease
Decreased VWF
Decreased platelet aggregation
Decreased platelet adhesion

A

Autoimmune disease

19
Q

TAFI target protein:

TFPI
Fibrinogen
Fibrin
VwF

A

Fibrin

20
Q

Which step requires calcium?

Factor VII activation
Factor XII activation
Factor XIII activation
Factor I activation

A

Factor XIII activation

21
Q

Giant platelet is associated with which condition:

Bernard soulier syndrome
Glanzmann’s thrombasthenia
Gaucher’s disease
All of the choices

A

Bernard soulier syndrome

22
Q

Platelet abnormality will affect both bleeding time and clotting time.
T/F

A

True

23
Q

Which of the following is associated with post transfusion purpura?

Non-immune thrombocytopenia / alloantibodies
Immune mediated thrombocytopenia / autoantibodies
Both of the above
Autoantibodies

A

Immune mediated thrombocytopenia / autoantibodies

24
Q

Thiazide diuretics results to?

Decreased platelet production
Decreased platelet survival
Both
Neither

A

Decreased platelet production

25
Q

Which of the following factors is used only in the extrinsic coagulation pathway ?

II
VII
V
VIII

A

VII

26
Q

Hereditary hemorrhagic telangectasia is a disorder of?

Platelets
Clotting proteins
Fibrinolysis
Connective tissue

A

Connective tissue

27
Q

Which of the following coagulation factors is considered to be labile?

II
III
V
VII

A

V

28
Q

What role does vitamin K play in the prothrombin group?

A. Provides surface on which the proteolytic reaction occurs
B. Protects them from inappropriate activation by compounds such as thrombin
C. Accelerates the binding of the serine protease and their cofactors
D. Carboxylates the factors to allow calcium binding

A

D. Carboxylates the factors to allow calcium binding

29
Q

Factor I deficiency will affect APTT and PT.

T/F

A

True

30
Q

Aspirin prevent platelet aggregation by inhibiting the action of which enzyme?

Prostacyclin Synthes
Phospholipase
Cyclooxygenase
TXA2 synthase

A

Cyclooxygenase

31
Q

Which statement regarding proteins C is correct:

Vitamin K independent
Fibrinogen activated
Activates V & VIII
Activity is enhanced by protein S

A

Activity is enhanced by protein S

32
Q

Thrombocytopenia may be associated with:

Postsplenectomy
Myeloproliferation
Hypersplenism
Acute blood loss

A

Hypersplenism

33
Q

The APTT is sensitive to a deficiency of which clotting factor?

Calcium
X
Both
None

A

None

34
Q

Which off the following factors will activate factor XI?

Stuart factor
Fibrinogen
Hageman factor
Plasma thromboplastin antecedent

A

Hageman factor

35
Q

Lumi-aggregation measures:

Platelet aggregation
Aggregation and ATP release
Platelet adhesion
GP1b

A

Aggregation and ATP release

36
Q

APTT is used to?

Monitor heparin therapy
Evaluate the common pathway
Both
None

A

Both

37
Q

Neurologic findings, maybe commonly associated with which of the following disorders?

HUS
TTP
ITP
PTP

A

TTP

38
Q

True of TTP & DIC:

APTT prolonged in DIC
Schistocytes are present in DIC
Platelet is decreased in TTP
PT is decreased in DIC

A

APTT prolonged in DIC

39
Q

Which of the following is most likely to be abnormal in patients taking aspirin?

Platelet morphology
Platelet count
Bleeding time
Prothrombin time

A

Bleeding time

40
Q

Platelet aggregation response for Glanzmann thrombasthenia:

Normal to ADP, decreased to ristocetin
Normal Ristocetin, decreased to Epinephrine
Normal aggregation to collagen, decreased to ADP and Ristocetin
Normal to ADP and Ristocetin, decreased to collagen

A

Normal Ristocetin, decreased to Epinephrine

41
Q

Thrombin-Thrombomodulin complex is necessary for the activation of:

Protein C
Antithrombin
Protein S
Factor V and VII

A

Protein C

42
Q

Scott syndrome will affect which of the following?

Platelet adhesion
Vasoconstriction
Secondary homeostasis
Fibrinolysis

A

Secondary homeostasis

Hema 2 (3 decks)

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