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Hema 2 > Lab | Semifinals > Flashcards

Lab | Semifinals Flashcards

1
Q

Happens at the platelet membrane

A

Secondary hemostasis

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2
Q

Inhibited by coagulation control proteins

A

Fluid phase (Secondary hemostasis)

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3
Q

Classification of blood factors

A

Substrate
Zymogen
Serine protease
Cofactor
Calcium

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4
Q

Substance where an enzyme acts

A

Substrate

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5
Q

Enzyme precursor

A

Zymogen

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6
Q

Inactive form of a coagulation factor

A

Zymogen

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7
Q

Proteolytic enzymes of trypsin family with reactive seryl amino acid residue in active sites

A

Serine protease

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8
Q

Needs to be present in addition to the enzyme so a particular reaction will be catalyzed (binds SP)

A

Cofactor

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9
Q

Needed for activation of coagulation factors

A

Calcium

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10
Q

Involves in all phase of coagulation except contact phase

A

Calcium

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11
Q

Flips to the outer surface on activation and is the phospholipid surface on which clotting enzymes assemble

A

Phosphatidylethanolamine

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12
Q

Present in the cell membrane of RBCs / normal cells

A

Phospholipid

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13
Q

Phospholipid is composed of

A

Lipid bilayers

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14
Q

Most coagulation factors are synthesized in the

A

Liver

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15
Q

Coagulation factors

A

I - Fibrinogen
II - Prothrombin
III - Tissue factor
IV - Calcium (ionized)
V - Proaccelerin
VI - Obsolete
VII - Proconvertin
VIII - Antihemophilic factor
IX - Plasma thromboplastin component
X - Stuart-prower factor
XI - Plasma thromboplastin antecedent
XII - Hageman factor
XIII - Fibrin stabilizing factor
Prekallikrein
HMWK (High Molecular Weight Kininogen)

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16
Q

Prothrombin

Factor:
Synonym/s:
Active form:
Pathway:

A

Factor II
Prethrombin (a2-globulin)
SP
Common

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17
Q

Tissue factor

Factor:
Synonym/s:
Active form:
Pathway:

A

III
Tissue thromboplastin (lipoprotein)
—
—

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18
Q

Calcium

Factor:
Synonym/s:
Active form:
Pathway:

A

IV
—
—
—

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19
Q

Proaccelerin

Factor:
Synonym/s:
Active form:
Pathway:

A

V
Labile factor / Accelerator globulin
SP
Common

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20
Q

Obsolete

Factor:
Synonym/s:
Active form:
Pathway:

A

VI
—
—
—

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21
Q

Proconvertin

Factor:
Synonym/s:
Active form:
Pathway:

A

VII
Stable factor / Serum prothrombin conversion accelerator (B-globulin)
SP
Extrinsic

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22
Q

Antihemophilic factor

Factor:
Synonym/s:
Active form:
Pathway:

A

VIII
Antihemophilic factor globulin / Antihemophilic factor A / Platelet cofactor 1
Cofactor
Intrinsic

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23
Q

Plasma thromboplastin component

Factor:
Synonym/s:
Active form:
Pathway:

A

IX
Christmas factor / Antihemophilic factor B / Platelet cofactor 2 (glycoprotein)
SP
Intrinsic

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24
Q

Stuart-prower factor

Factor:
Synonym/s:
Active form:
Pathway:

A

X
Stuart factor / Prower factor / Auto prothrombin III (glycoprotein)
SP
Common

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25
Q

Plasma thromboplastin antecedent

Factor:
Synonym/s:
Active form:
Pathway:

A

XI
Antihemophilic factor C (B2-globulin)
SP
Intrinsic

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26
Q

Hageman factor

Factor:
Synonym/s:
Active form:
Pathway:

A

XII
Glass factor / Contact factor
SP
Intrinsic

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27
Q

Fibrin stabilizing factor

Factor:
Synonym/s:
Active form:
Pathway:

A

XIII
Laki-Lorand factor / Fibrinase / Plasma transglutaminase / Fibrinoligase
Transglutaminase
Common

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28
Q

Prekallikrein

Factor:
Synonym/s:
Active form:
Pathway:

A

—
Fletcher factor
SP
Intrinsic

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29
Q

HMWK

Factor:
Synonym/s:
Active form:
Pathway:

A

—
Fitzgerald factor / Williams factor / Contact activation cofactor / Flaujeac factor (glycoprotein)
Cofactor
Intrinsic

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30
Q

3 stages in secondary hemostasis

A

Generation of thromboplastin / Enzymatic phase
Conversion of prothrombin to thrombin / Polymerization
Conversion of Fibrinogen to Fibrin clot / Coagulation/clotting

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31
Q

Coagulation factors associated w/ Stage 1

A

V, VII, VIII, IX, X, XI, XII

5, 7, 8, 9, 10, 11, 12

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32
Q

Very sensitive coagulation factors

A

V and VIII

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33
Q

Coagulation factors associated w/ Stage 2

A

II

34
Q

Coagulation factors associated w/ Stage 3

A

I and XIII

35
Q

Coagulation factors that are vitamin K dependent

A

II, VII, IX, X, (and Proteins C & S)

1972

36
Q

Coagulation factors present in plasma

A

I, V, VIII, XI, XII, XIII, Prekallikrein, and HMWK

1, 5, 8, 11, 12, 13

37
Q

Produced in endothelial cells and megakaryocytes

A

VonWillebrand factor

38
Q

Stored in a-granules of platelets and in “Weibel-Palade bodies” of endothelial cells

A

VonWillebrand factor

39
Q

Formation of complexes

A
  • TF, F VIIa, PL, and Ca
  • F IXa, F VIII, Ca, and PF3 = Tenase
  • F Xa, F Va, Ca, and PF3 = Prothrombinase
40
Q

Starts at factor XII and culminates in fibrin polymerization

A

Intrinsic pathway

41
Q

a.k.a. Tissue factor pathway

A

Extrinsic pathway

42
Q

Where both pathways meet and ends in formation of fibrin clot

A

Common pathway

43
Q

Factors associated w/ Intrinsic pathways

A

XII, Pre-, HMWK, XI, IX, VIII

8, 9, 11, 12, Pre-, and HMWK

44
Q

Factors associated w/ Extrinsic pathway

A

VII

(involved in close circulation)

45
Q

Factors associated w/ Common pathway

A

X, V, Prothrombin, Fibrinogen, XIII

1, 2, 5, 10,13

46
Q

Factor that hides in the tissues and will only go out if it is activated

A

III / Tissue factor

47
Q

Thrombin sensitive group

A

Fibrinogen

48
Q

Calcium dependent, Vit. K independent
1, 5, 8, 13
Consumed during coagulation
Present in plasma, absent in serum
Increased: pregnancy, inflammatory response, & in women on oral contraceptives, stress
Factors 5 & 8 = decreased in-vitro storage

A

Fibrinogen group

49
Q

Plasma proteins?

A

Active phase reactants; inflammatory markers

50
Q

Calcium and Vit. K dependent
2, 7, 9, 10 and Proteins C & S
Stable & well-preserved in stored plasma
Adsorbable factors
Present in both serum (except factor 2) and plasma
Coumarin drugs - competes w/ Vit. K
Requires Ca or a cofactor to bind with phospholipid surfaces

A

Prothrombin group

51
Q

Vit. K sources

A

Leafy vegetables, Bacteroides fragilis, and E. Coli

52
Q

Adsorbable factors are treated w/

A

Aluminum hydroxide and Barium sulfate
- detects the presence of prothrombin group
- if plasma are treated with these, prothrombin group is loss

53
Q

Ca and Vit. K independent
11, 12, Pre-, and HMWK
Involved in contact phase
Not adsorbed, not consumed during coagulation
Relatively stable
Requires contact of negative-charged surface for activation

A

Contact group

54
Q

Prekallikrein & HMWK function in the activation of

A

Plasminogen in the fibrinolytic system

55
Q

Included in the a-granules and promotes growth in injured tissue sites

A

Platelet-derived growth factor

56
Q

Removes the clot by destroying it via fibrinolysis

A

Plasminogen

57
Q

After the fibrin clit has been stabilized by Factor XIIIa, the platelets inside the clot releases strands that would pull the clot inward making the whole clot denser and releasing excess serum

A

Clot retraction

58
Q

Activator on intrinsic and extrinsic pathway

A

Injury

59
Q

Calcium dependent, Vit. K independent

A

Fibrinogen group

60
Q

What group belongs to I, V, I, XIII

A

Fibrinogen group

61
Q

Present in plasma, absent in serum

A

Fibrinogen group

62
Q

Consumed during coagulation

A

Fibrinogen group

63
Q

pregnancy, inflammatory reaction, oral contraceptive, stress

A

Increased

Fibrinogen group

64
Q

Factors that are Decreased in in vitro storage

A

V & VIII

Fibrinogen group

65
Q

Calcium and Vit. K dependent

A

Prothrombin group

66
Q

What group belongs to II, VII, IX, X, and Proteins C & S

A

Prothrombin group

67
Q

Stable and well preserved in stored plasma

A

Prothrombin group

68
Q

Adsorbable factors

A

Prothrombin group

69
Q

Vit. K is necessary for their synthesis in the liver

A

Prothrombin group

70
Q

Present in both serum (except Factor II) and plasma

A

Prothrombin group

71
Q

Competes with Vit. K

A

Coumarine drugs

Prothrombin group

72
Q

Requires calcium or a cofactor to bind with phospholipid surface

A

Prothrombin group

73
Q

Calcium and Vit. K independent

A

Contact group

74
Q

What group belongs to XI, XII, Prekallikrein, amd HMWK

A

Contact group

75
Q

Involved in contact phase

A

Contact group

76
Q

Not adsorbed nor consumed during coagulation

A

Contact group

77
Q

Relatively stable

A

Contact group

78
Q

Requires contact of gram-negative charged surface for activation

A

Contact group

79
Q

Factors that have serine protease as an active form

A

II, V, VII, IX, X, XI, XII, Prekallikrein

2, 5, 7, 9, 10, 11, 12

80
Q

Factors that have cofactor as their active form

A

VIII and HMWK

8

81
Q

Factor that have transglutaminase as its active form

A

XIII

13

Hema 2 (3 decks)

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