Lecture: Lewis, P, Ii, MNS and Lutheran Blood Group Systems Flashcards
An alleles that makes no antigen and are very rare
Silent or amorphic alleles
A rare autoimmune disorder seen in patient with tertiary syphilis
Paroxysmal Cold Hemoglobinuria
serve as a receptor for P-fimbriated uropathogenic E.coli a UTI causative agent
P system antigen
early abortion is associated with what antibody?
Anti-PP1k and Anti-P
Most commonly encountered lewis antibody and is often detected at RT tests but sometimes react with 37C and in the indirect antiglobulin Test
Anti-Le^a
A common phenotype that individuals react with Anti-P1 and Anti P commercial reagents
P1
A rare phenotype that reacts with Anti-P1 and anti-pk, but not with anti-P
P1k
common precursor for P blood group antigens
lactosylceramide
what immunoglobulin does the lewis antibodies have?
IgM
Found as naturally occurring alloantibody in the sera of Pk individuals. reactivity is similar to the Anti-PP1Pk and rarely seen but very significant in transfusion because it is hemolytic
ALLOANTI-P
Antigens are resistant to what enzymes treatment?
ficin and papain, DTT, ang glycine-acid EDTA
originally called Anti-Tja, produced by p null indiivudals early in life without rbc
Anti-PP1Pk
Common, naturally occurring IgM in sera of P1 individuals
Anti-P1
Soluble Lewis antigens are found in secretions particularly in where? and in what substance?
Saliva; as glycoproteins
description of which antigens are present on an
individual’s RBCs and simply indicates the results of serologic
tests on those RBCs
phenotype
