Lecture: Lewis, P, Ii, MNS and Lutheran Blood Group Systems Flashcards
An alleles that makes no antigen and are very rare
Silent or amorphic alleles
A rare autoimmune disorder seen in patient with tertiary syphilis
Paroxysmal Cold Hemoglobinuria
serve as a receptor for P-fimbriated uropathogenic E.coli a UTI causative agent
P system antigen
early abortion is associated with what antibody?
Anti-PP1k and Anti-P
Most commonly encountered lewis antibody and is often detected at RT tests but sometimes react with 37C and in the indirect antiglobulin Test
Anti-Le^a
A common phenotype that individuals react with Anti-P1 and Anti P commercial reagents
P1
A rare phenotype that reacts with Anti-P1 and anti-pk, but not with anti-P
P1k
common precursor for P blood group antigens
lactosylceramide
what immunoglobulin does the lewis antibodies have?
IgM
Found as naturally occurring alloantibody in the sera of Pk individuals. reactivity is similar to the Anti-PP1Pk and rarely seen but very significant in transfusion because it is hemolytic
ALLOANTI-P
Antigens are resistant to what enzymes treatment?
ficin and papain, DTT, ang glycine-acid EDTA
originally called Anti-Tja, produced by p null indiivudals early in life without rbc
Anti-PP1Pk
Common, naturally occurring IgM in sera of P1 individuals
Anti-P1
Soluble Lewis antigens are found in secretions particularly in where? and in what substance?
Saliva; as glycoproteins
description of which antigens are present on an
individual’s RBCs and simply indicates the results of serologic
tests on those RBCs
phenotype
What test determine only the RBC phenotype
Serologic test
What gene must be present for a precursor substance to be
converted to Lea and present for
conversion to Leb
Le gene for Lea
Se gene for Leb
patient with Hodgkin’s Lymphoma
LUKE (LKE) ANTIGEN
True or False.All p and PK individuals are Luke+
False kay neg ans ana
Mutations that result in inactivation of the fucosyltransferase
(amorphic/silent le allele
RBCs with Le(a-b-) phenotype
Soluble Lewis antigens are found in secretions particularly
in saliva as
glycoproteins
Primary source of Lewis glycolipid in plasma
GI tract
serve as receptors for P-fimbriated
uropathogenic E.coli (a UTI causative agent
P system antigens
receptor for shiga toxins (Shigella dysentery) and
E.coli-associated hemolytic uremic syndrome;
recent studies show it also provides some protection against
HIV infection of peripheral blood mononuclear cells
Pk antigen
receptor of human parvovirus B19
P
which I/i antibodies associate with HDFN
Anti-i kay ang Anti-I is IgM therefore, dili sha mo associate with HDFN
cold agglutinin syndrome and M. pneumoniae
aNTI-I
infectious mononucleosis
Anti-i
responsible for synthesizing some of the antigen or
encoding the different enzymes that will synthesize the
different antigens of the P blood group
P1PK gene and P gene
congenital cataract in
Asians
Adult i phenotype
T/F. MNS are not commonly encountered in BB
T
M AND N ANTIGENS Found in
glycophorin A (
M and N differ from their amino acid residues at position sa asa man isulat
- M: (1) serine, (5) glycine
* N: (1) leucine, (5) glutamic acid
S AND s ANTIGENS Found in
glycophorin B
S AND s ANTIGENS Differentiated by amino acid at position 29:
- S: methionine
* s: threonine
t/f. S AND s ANTIGENS are Less easily degraded by enzymes because antigens are located
farther down the glycoprotein and enzyme-sensitive sites are
less accessible
T
True or False. RBCs with null phenotypes are very helpful in
evaluating antibodies to unknown high-prevalence
antigens (
True
