Lecture: Duffy, Kell, Kidd and Miscellaneous Blood Groups Flashcards
a null phenotype were found to resist infection i vitro by the
monkey malaria organism Plasmodium knowlesi later it
was known that these RBCs also resist infection by P.vivax,
which causes human malaria
Fy(a-b-) RBCs
gene responsible for this null phenotype; exceedingly
rare in whites
Fy gene
Most important Duffy antigens in routine blood bank serology
- Common in red cells of Caucasians
Fy a AND Fy b ANTIGENS
Fy(a-b-) or Duffy null phenotype is predominant in what race?
Blacks/people with African-American ethnicity
Duffy antigens reside or bind on a glycoprotein of 336 (or 338) amino
acids that has two N-glycosylation sites
Duffy Antigen
Receptor for Chemokines (DARC
defines the
Fy a and Fy b polymorphism
AA at position 42 on the Duffy glycoprotein
Fy a → glycine
- Fy b → aspartic acid
common antibody for duffy system
less common antibody for duffy system
Anti-Fy a
Anti-Fy b
Kell glycoprotein is
fairly resistant to proteolytic digestion by papain and ficin;
but is exquisitely sensitive to sulfhydryl-reducing agents due to lowly folded nature
False. kay ang c-terminal is highly folded which makes it fairly resistant
Kell antigen expression is dependent upon the presence of
Xk protein
Absence of Xk protein
McLeod phenotype
RBC that Lack expression of all Kell antigens and Have no membrane abnormalities and survive normally in
the circulation
K0 RBCs
is the most common antibody seen in the blood
bank and Most appear to be induced by pregnancy and transfusion
Anti-K
most reliable method of
detection ANti-K
Indirect Antiglobulin Test
Very rare; X-linked inheritance through a carrier mother
(thus all affected are male)
• Has been associated with several mutations and
deletions at the XK locus
McLeod phenotype
member of the urea
transporter gene family
Kidd glycoprotein
