Lecture Exam 1 Flashcards

1
Q

Fibrous Connective Tissue - Loose Connective Tissue

A
  • Has a lot of matrix with fewer fibers – more ground substance
  • Areolar Tissue
  • Reticular Tissue
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2
Q

Fibrous Connective Tissue - Dense Connective Tissue

A
  • Lots of fibers with little ground substance
  • Dense Regular Connective Tissue
  • Dense Irregular Connective Tissue
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3
Q

Loose Connective Tissue: Areolar Tissue

A

Structure:
- Loosely organized fibers
- Contains all 6 cell types (fibroblasts, plasma cells, adipose, etc)
- Cells are spaced out
- Fibers are not in any direction, overlapping themselves
- Spread
- Has a lot of ground substance – a lot of fibroblasts
- Thicker fibers – collagen
- Smaller fibers - elastin

Function:
- Tissue under epithelium
- Contains blood vessels & nerves that nourish the epithelium
- Ability to pull in different direction – a lot of collagen fibers

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4
Q

Loose Connective Tissue: Reticular Tissue

A

Structure:
- A lot of ground substance
- Ground substance is full of blood cells (Typically, red blood cells)
- Mesh of reticular fibers (tend to look like spiderwebs) and fibroblasts

Function:
- Resists stretch in many directions
- Provides framework for organs in immune system (bone marrow, spine, thymus, krypton nodes)

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5
Q

Dense Connective Tissue: Dense Regular Connective Tissue

A

Structure:
- Has a lot of fibers
- Also called white fibers
- Tightly packed, usually parallel, collagen fibers
- Few cells that make collagen

Function:
- Make up tendons & ligaments
- Resist pull in a single direction
- Flexible in a side-to-side direction

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6
Q

Dense Connective Tissue: Dense Irregular Connective Tissue

A

Structure:
- Lots of fibers, thick bundles of collagen, a few cells and very little ground substance
- Collagen bundles are oriented in many different directions

Function:
- Resist pull in many directions
- Stronger than reticular
- Find it in dermis of skin (lower)
- Keeps skin from detaching

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7
Q

Adipose Tissue

A

Structure:
- Fat tissue
- Made of primarily cells called adipocytes
- Usually In areolar, reticular, blood cells –tissue surround and enter the adipose tissue

Function:
- Store triglycerides (lipids)
- Release triglycerides when the body needs energy
- Also acts as cushion for organs

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8
Q

White Fat

A

Structure:
- Adipocytes grow in size as they store more triglycerides
- Triglycerides are stored in the center of the cells
- If one has a lot of triglycerides – cytoplasm and nucleus are pushed to the sides

Location and Function:
- More abundant
- Thermal insulation
- Anchors and cushions your organs
- Contributes to body contours
- Stores and releases triglycerides as needed
- Under all surfaces of the body and around organs

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9
Q

Brown Fat

A

Structure:
- Stores triglycerides in multiple globules instead of one large one
- Lots of blood vessels
- Many mitochondria

Location and Function:
- Location – in young babies and children (very abundant) – fat pads in shoulders, upper back and around the kidneys – important to keep infants warm
- Adults have it in the same place but its smaller
- Generates heat
- Mitochondria don’t make ATP from fat- release it as heat
- Abundant in hibernating animals

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10
Q

General Cartilage Characteristics

A
  • Stiff connective tissue with a flexible, rubbery matrix
  • Gives its organs their structure and support (ex. Shape of nose)
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11
Q

Formation of Cartilage

A
  • Chondroblasts
  • Matrix
  • Chondrocytes
  • Lacunae
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12
Q

Cartilage - chondroblasts

A
  • Cells that make matrix of cartilage
  • Found outside of cartilage
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13
Q

Cartilage - Matrix

A
  • Rich in GAGs and collagen
  • Chondroblasts make matrix
  • Lacks blood vessels
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14
Q

Cartilage - Chondrocytes

A
  • Chondroblast that have gotten trapped in their own matrix
  • No longer make matrix – alive but not productive
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15
Q

Cartilage - Lacunae

A

Chambers that hold chondrocytes

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16
Q

Matrix and Repair of Cartilage

A
  • Matrix (GAGs and collagen)
  • Lack of Capillaries (No blood in tissue – nourished from outside)
  • Slow Repair (Repairs slowly if at all)
  • Must repair from outside in
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17
Q

Cartilage Growth - Perichondrium

A
  • Membrane outside of cartilage
  • Contains blood vessels
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18
Q

Cartilage Growth - Reserve Chondroblasts

A
  • Chondroblasts in mature cartilage that divide to replace cartilage tissue
  • Under perichondrium, near blood
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19
Q

Cartilage Types

A
  • all have chondrocytes in lacune
  • Hyaline (Matrix is clear and glassy)
  • Elastic (Has many elastic fibers)
  • Fibrocartilage (Matrix has many collagen fibers)
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20
Q

Hyaline Cartilage

A

Structure:
- Chondrocytes in lacunae
- Clear glossy matrix
- Made of GAGs with think and fine collagen

Function:
- Hard cartilage
- Doesn’t have a lot of stretch
- Rings around the trachea – holds trachea open
- Placeholder for bones in an infant and early childhood

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21
Q

Elastic Cartilage

A

Structure:
- Chondrocytes in lacunae
- Matrix has GAGs and a visible array of elastic fibers

Function:
- Stretchy cartilage
- Found in ears, nose

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22
Q

Fibrocartilage

A

Structure:
- Heavy and abundant collagen fibers in matrix
- Chondrocytes in lacunae

Function:
- Springy
- Good padding
- Makes up intervertebral disc – pads area between spinal cord

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23
Q

Bone Characteristics

A

Osseous Tissue - Aka bone:
- Hard, calcified connective tissue
- Composes skeleton

Other Components:
- Osseous tissue – only base tissue
- Also contains cartilage, bone marrow, dense irregular connective tissue, and others to make up the bone organs

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24
Q

Types of Osseous Tissue - Spongy Bone

A
  • Looks like a sponge
  • Has many openings and delicate slippers
  • Inside of the bone
  • Protects bone from being too heavy
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25
Q

Types of Osseous Tissue - Compact Bone

A
  • Hardened solid bone tissue
  • Very dense with no spaces
  • Makes up external spaces of bone
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26
Q

Compact Bone Structure - Central Canal

A
  • tree trunk
  • Middle of each tree trunk
  • Extend down the entirety of the bone
  • Openings for blood vessels and nerves (makes it able to repair quickly)
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27
Q

Compact Bone Structure - Lamellae

A
  • Concentric rings around each central – layers if bone tissue around each canal (that deposit)
  • Separated by collagen fibers
  • tree trunk
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28
Q

Compact Bone Structure - Osteon

A
  • tree trunk
  • The entirety of the tree – central canal with all its rings (the whole structure)
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29
Q

Compact Bone Structure - Lacunae

A
  • Sitting around lamella – in bone, lacunae hold osteocytes (mature bone cells)
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30
Q

Compact Bone Structure - Canaliculi

A
  • Channels between lacunae – connect osteocytes to each other
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31
Q

Compact Bone Structure - Periosteum

A
  • Membrane on outside of bone
  • Holds osteoblast underneath
  • makes bone matrix
  • Osteoblast get trapped in lacunae - becomes osteocytes
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32
Q

Bone Matrix

A

Collagen:
- Between lamellae
- Allow bone to bend, not stretch

Minerals:
- Calcium and phosphates
- Makes bone matrix hard

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33
Q

Fluid Connective Tissue - Blood

A

Composition:
- Cells in a liquid matrix (plasma)

Function:
- Carry nutrients to body and wastes away from body

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34
Q

Nervous Tissue

A

Neurons:
- Large cells that signal in nervous tissue

Neuroglia:
- Smaller cells that support the neurons

Function:
- Signal for communication in body

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35
Q

Muscular Tissue Types

A

Features:
- Contractile – cells shorten

Types - 3:
- Skeletal – attach bones (voluntary signal)
- Cardiac – heart (involuntary signal)
- Smooth – organs (involuntary signal)

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36
Q

Skeletal Muscle

A

Structure:
- Long cells with several nuclei in them
- Cells are unbranched – single line
- Striated (light and dark bands)

Function:
- Attached to bones
- Under voluntary control

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37
Q

Cardiac Muscle

A

Structure:
- Striated, single cells, separated by intercalated discs (dark bands)
- Cells are branched

Function:
- Only in heart, involuntary

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38
Q

Smooth Muscle

A

Structure:
- Non striated
- Spindle-shaped
- One nucleus

Function:
- Are in blood vessels and organs
- Contract involuntarily

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39
Q

Connections Between Cells - Anchorage to Other Cells

A
  • Cells must be attached to other cells to be cohesive
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40
Q

Connections Between Cells - Anchorage to Matrix

A
  • ALSO - Cells must be attached to matrix to be cohesive
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41
Q

Types of Cell Junctions

A
  • Tight Junctions
  • Desmosomes
  • Gap Junctions
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42
Q

Tight Junctions

A
  • Zipper like
  • Attach cells tightly
  • Stop material from getting between cells
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43
Q

Desmosomes

A
  • Buttons
  • Attach cells loosely
  • Material can get between
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44
Q

Gap Junctions

A
  • Doors
  • Pores between cells
  • Allows cytoplasm to pass
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45
Q

Gland

A

Definition:
- Cell within tan organ that secretes substances

Secretions:
- Products that’s useful for the body
- Excretion waste product

Structure:
- Gland is made of mostly epithelial tissue, usually simple cuboidal epithelium
- Often connected to a channel called a duct – releases a products to surface

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46
Q

Exocrine Glands

A
  • Secretes products through a duct to the surface of the body
  • Exo – outside (skin, digestive system or mucous membrane)
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47
Q

Endocrine Glands

A
  • Inside
  • Secretes products into the bloodstreams
  • Thyroid
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48
Q

Secretion of Serous Glands

A
  • Produce a watery fluid with enzymes
  • Sweat glands
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49
Q

Secretion of Mucous glands

A
  • Produce mucus – thick slimy fluid
  • Lacs enzymes but for lubrications
  • Traps debris
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50
Q

Secretion of Mixed Glands

A
  • Produce serous fluid and mucus
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51
Q

Modes of Exocrine Gland Secretion

A

Merocrine:
- Produce secretions inside the cell,
- Sweat
- release them by exocytosis into the environment

Apocrine:
- secrete fat from droplets that bud from cell surface (mammary glands)

Holocrine:
- release wide cells that then break down and release products (sebaceous glands )

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52
Q

Body Membranes - Cutaneous membrane

A

Skin – made of epidermis and dermis

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53
Q

Body Membranes – Mucous membrane

A
  • Line areas of body that lead to outside mouth, nose, throat, urinary, digestive
  • Produce mucus
54
Q

Body Membranes – Serous membrane

A
  • Line internal membranes – linings of body cavities
  • Pericardium, Pleura, peritoneum
55
Q

Body Membranes - Endothelium

A

Internal lining of blood vessels

56
Q

Integumentary System

A

Skin:
- Cutaneous membrane outside body
- Sensory organ - touch, temperature etc.

Hair:
- Dead tissue/filaments that extend from most parts of the skin

Nails:
- Covers tips of the digits for primarily protection
- Allows to dig into

Associated Glands:
- Sweat, subclades, others

57
Q

The Skin (Integument)

A

Location:
- Covers exterior surface of body and some interior surfaces

Quantity:
- 15% of body weights
- Body’s largest and heaviest organ

58
Q

Layers of the Skin

A
  • Epidermis
  • Dermis
  • Hypodermis
59
Q

Epidermis - skin

A
  • On the outside
  • Thick layer
  • Stratified squamous epithelium
60
Q

Dermis - Skin

A
  • Under epidermis
  • Made of connective tissue
  • Alveolar, reticular, dense irregular.
  • Contains blood vessels and nerves
61
Q

Hypodermis - skin

A
  • Not part of the skin
  • contains connective tissue – lots of adipose tissue to pad skin (thermal insulation to skin)
62
Q

Thin Skin

A
  • Rest of body
  • Thinner epidermis
  • Has hair follicles, sebaceous glands, sweat glands
  • Loosely organized.
63
Q

Thick Skin

A
  • Palms, soles of feet, fingers, toes
  • Sweat glands but lack hair follicles and sebaceous glands
  • Thick layer of epidermis
  • Epidermis tightly compacted
64
Q

Functions of the Skin

A
  • Resistance to Trauma and Infection
  • Other Barriers
  • Vitamin D Synthesis
  • Sensation
  • Thermoregulation
  • Nonverbal Communication
65
Q

Functions of the Skin - Resistance to Trauma and Infection

A
  • Has many mechanisms to prevent and heal from trauma
  • Skin is waterproof
  • Nutrient poor
  • Microbes do not grow well on skin
66
Q

Functions of the Skin - Other Barriers

A
  • Barrier to water – prevents absorption of outside water and the loss of internal water
  • Impermeable to most drugs and most toxins
67
Q

Functions of the Skin - Vitamin D Synthesis

A

Carries out the first step of vitamin D synthesis (requires sunlight)

68
Q

Functions of the Skin - Sensation

A

Sense of touch and a lot of other senses are carried out by skin

69
Q

Functions of the Skin - Thermoregulation

A
  • Sense of hot and cold is in the skin
  • Blood vessels near the skin constrict to stop heat loss when cold (skin turns blue or pale when cold)
70
Q

Functions of the Skin - Nonverbal Communication

A
  • Muscles that attach to skin convey emotion
  • Self image
71
Q

The Epidermis

A

Outside of skin

Composition:
- Stratified squamous epithelium
- Keratinized – surface contains intermediate filament called keratin

Nutrition:
- Epidermis lacks blood vessels and nerves – skin surface is often dead

Blood Vessels and Nerves:
- In dermis – nourish and give sensation from underneath epidermis (base of epidermis is alive)

72
Q

Cells of the Epidermis

A
  • Stem Cells
  • Keratinocytes
  • Melanocytes
  • Tactile cells
  • Dendritic cells
73
Q

Epidermis - Stem Cells

A
  • Only cells in the epidermis that can divide
  • Sit on the basement membrane
  • Become keratinocytes
74
Q

Epidermis - Keratinocytes

A
  • Normal cells making up stratified squamous epithelium – make keratin
75
Q

Epidermis - Melanocytes

A
  • Only at the basement membrane
  • Synthesis brown to black pigment melanin – secrete melanin to nearby cells
  • Keratinocytes uptake melanin and use it to shield their nuclei form UV light
76
Q

Epidermis - Tactile Cells

A
  • Very few cells
  • Receptors for very light touch
  • Connected to a nerve
77
Q

Epidermis - Dendritic Cells

A
  • In epidermis
  • Immune cells that alert the immune system for any invaders
78
Q

Layers of the Epidermis

A
  • Stratum basale
  • Stratum Spinosum
  • Stratum Granulosum
  • Stratum Lucidum
  • Stratum Corneum
79
Q

Layers of the Epidermis - Stratum basale

A
  • A layer of cuboidal epithelium at the basement membrane
  • Melanocytes, tactile cells, stem cells inside – where stem cells divide to make keratinocytes
80
Q

Layers of the Epidermis - Stratum Spinosum

A
  • Several layers of living keratinocytes
  • Usually, thickest
81
Q

Layers of the Epidermis - Stratum Granulosum

A
  • Three to five layers of very flat keratinocytes
  • See more of it in thick cells
  • Stains dark because the keratinocytes are starting to die and produce keratohyalin granules
82
Q

Layers of the Epidermis - Stratum Lucidum

A
  • Only in very thick skin
  • Made of keratinocytes that are packed with clear protein eleidin
  • Cells have no nuclei or organelles – very clear
83
Q

Layers of the Epidermis - Stratum Corneum

A
  • Outside layer of the skin
  • Made of 30 layers of dead, scaly, keratinized cells
  • Durable surface – strong and abrasion resistant
  • Surface sloughs off
84
Q

The Dermis

A

Composition:
- Primarily connective tissue
- Lots of collagen
- Also, reticular and elastic fibers

Blood Vessels, Nerves and Glands:
- Has many blood vessels, nerves, glands – well nourished

Muscles:
- Some skeletal muscles
- Attached to dermis – produce expressions, wrinkles

Dermal Papillae:
- Wavy boundary between epidermis and dermis – make fingerprints

85
Q

Layers of the Dermis - Papillary Layer

A
  • Upper dermis near the dermal papillae
  • Made of areolar tissue
86
Q

Layers of the Dermis - Reticular Layer

A
  • Lower layer
  • Made of dense irregular connective tissue
  • Has collagen, sometimes reticular fibers, some adipocytes
  • Stretch marks
87
Q

The Hypodermis

A

Subcutaneous tissue

Tissue:
- Made of areolar and adipose tissue

Function:
- Contains subcutaneous fat – energy reservoir and thermal insulation

88
Q

Skin Color

A
  • Melanin
  • Melanocytes
  • Forms of melanin
89
Q

Skin Color - Melanin

A
  • Dark brown/black pigment made by melanocytes – scatter to surrounding keratinocytes
  • Shields nuclei from UV lights
90
Q

Skin Color - Melanocytes

A
  • Cells that produce melanin
  • melanocytes are roughly equivalent in all skin colors but produce more melanin in people with darker skin.
91
Q

Skin Color - Forms of melanin

A
  • 2 forms of melanin (Eumelanin and pheomelanin)
  • Eumelanin - brownish black
  • Pheomelanin – reddish yellow

Dark Skin:
- More melanin
- breaks down more slowly

Light Skin:
- Less melanin
- Breaks down easier/more quickly

92
Q

Other Skin Color Considerations - Suntan

A
  • Over production of melanin when exposed to the sun (UV – light)
93
Q

Other Skin Color Considerations - Hemoglobin

A

Imparts a reddish color to skin (in blood)

94
Q

Other Skin Color Considerations - Carotene

A

Imparts a yellow color to skin – in yellow/orange vegetables

95
Q

Other Skin Color Considerations - Cyanosis

A

Blue color of skin from lack of oxygen

96
Q

Other Skin Color Considerations - Erythema

A
  • Abnormal redness from exercise or heat
  • Because blood vessels near the skin are more open to release your heat
97
Q

Other Skin Color Considerations - Pallor

A

Pale color – no or little blood flow to the skin

98
Q

Other Skin Color Considerations - Albinism

A
  • Lack of melanin in the skin
  • Genetic phenomenon
99
Q

Other Skin Color Considerations - Jaundice

A
  • Yellow skin and yellow eyes
  • Yellow correlation caused by a malfunction in the liver
  • Happens in babies and is an accumulation of bilirubin in skin
100
Q

Other Skin Color Considerations - Hematoma

A
  • Bruise – see clothed blood through your skin
  • Injury in dermis
101
Q

Skin Markings - Friction Ridges

A
  • Fingerprints
  • From dermal pupillae
  • Occur early on - just before birth
  • For more grip
102
Q

Skin Markings - Flexion Lines

A
  • Lines on palms, wrists, ankles etc.
  • Folds of deeper connective tissue in areas where you bend an appendage
  • Protects the fold
103
Q

Skin Markings - Moles

A

-Elevated patch of melanized skin - often has hair

104
Q

Skin Markings - Freckles

A
  • Aggregate of melanized keratinocytes
  • Flat patches
  • Sometimes because of sun exposure
  • Sometimes inherited
105
Q

Skin Markings - Hemangioma

A

Patch of skin which is discolored by benign tumors of the blood capillaries (Pictures)

106
Q

Hair – aka pilus

A

Composition:
- Slender filament of keratinized cells

Location:
- Grows through a tub called a hair follicle
- In the dermis but pierce the epidermis and goes out

107
Q

Types of Hair

A
  • Lanugo
  • Vellus Hair
  • Terminal Hair
108
Q

Types of Hair - Lanugo

A

Fine, downy, unpigmented hair on a fetus and a newborn

109
Q

Types of Hair - Vellus Hair

A
  • Fine and pale hair in young children (except for the eyebrows, eyelashes and scalp
  • 2/3 of hair in women
  • 1/10 of hair in men
110
Q

Types of Hair - Terminal Hair

A
  • Long, pigmented hair
  • Eyebrows, eyelashes and scalp of all people
  • Males and females – grows in other places and forms axillary and pubic hair
  • Males – forms facial hair, trunk and limbs (has more hair because of testosterone
111
Q

Structure of a Hair Follicle

A

Melanized (contain pheomelanin and/or eumelanin)

Shaft:
- Above the skin
- Keratinized dead cells
- Oldest hair cells

Root:
- Beneath the skin
- Most of it is dead and made of keratinized dead cells (except the bulb which is living

Bulb:
- Dilation at base of hair in dermis – living cells with a blood supply

112
Q

Layers of Hair - Medulla

A
  • Inside of the hair
  • Contains packed cells with melanin in it
  • Core of cells around an open-air space
113
Q

Layers of Hair - Cortex

A
  • Outside of hair
  • Many layers of melanized and keratinized cells
114
Q

Layers of Hair - Cuticle

A
  • Several layers of very thin, scaly cells that overlap
  • Very outside of the hair
115
Q

Layers of Hair

A
  • Medulla
  • Cortex
  • Cuticle
116
Q

Hair Follicle

A

Tube around the hair

Epithelial Root Sheath:
- Extension of epidermis
- Carries around entire hair
- Touches hair
- Divides at base to make new hair

Connective Tissue Root Sheath:
- Below epithelial
- Root sheath – collagen, support epithelial root sheat

117
Q

Hair Receptors

A

Function:
- Neurons that encase each hair – sense movement of the hair

Piloerector Muscle – arrector pili muscle:
- Muscle that responds to activation of hair receptors by making hair stand or end

117
Q

Hair Receptors

A

Function:
- Neurons that encase each hair – sense movement of the hair

Piloerector Muscle – arrector pili muscle:
- Muscle that responds to activation of hair receptors by making hair stand or end

118
Q

Nails

A

Composition:
- Clear, hard derivatives of stratum corneum
- Thin, dead, scaly cells packed together and filled with hard keratin

Function:
- Hard, picking apart food, other manipulation
- Allow for more sensitive fingertips

119
Q

Parts of a Nail

A

Nail Plate:
- Hard part of the nail
- Free edge over the tip and the part you see over skin (part that you paint)

Nail Fold:
- Skin that rises around nail

Nail Bed:
- Skin that underlies the nail (under the nail plate)
- Layer of epidermis – hyponychium

Nail Matrix:
- Proximal end of the nail
- Where mitosis of the nail occurs
- Layer of stratum basale

Cuticle:
- Protective layer of skin

120
Q

Cutaneous Glands

A

Merocrine Sweat Glands
- Whole skin

Apocrine Sweat Glands
- Pheromone release
- Armpits – pubic

Sebaceous Glands
- Hair follicles – for lubrication

Ceruminous Glands
- Ear

Mammary Glands
- In breasts

121
Q

Apocrine Sweat Glands

A
  • Actually, merocrine secretion (thin watery fluid)
  • Pheromones for sexual attraction – pleasantly fragrant
  • When metabolized by skin bacteria – start to smell
  • Arise in puberty

Location:
- Some in groin, anal region, axilla, areola, beard area in mature males

Structure and Secretion:
- Connected to hair follicles
- Ducts secrete the products out of the hair follicle

122
Q

Merocrine Sweat Glands

A

Location:
- Distributed over the whole body

Structure and Secretion:
- Made of a ball of cells with a duct leading to skin surface
- Not connected to a hair follicle
- Merocrine secretions of water and salt – evaporate, cools body down

123
Q

Myoepithelial Cells

A

Location:
- Both in apocrine and merocrine sweat glands
- In deep end of gland

Function:
- Contract to force sweat up

124
Q

Sebaceous Glands

A

Structure:
- Holocrine glands
- Not typically sweat glands
- Multiple layers of cuboidal epithelium
- Always connected to a hair follicle

Secretion:
- Known as sebum
- Holocrine secretion – make an oily secretion that lubricates your hair (keeping it from being dry and cracked)
- Distributed by a hair brush

125
Q

Ceruminous Glands

A

Location:
- In the ear canal
- Yellow, waxy secretion
- Combines with sebum and dead cells to form earwax

Function:
- Earwax - known as cerumen – keeps your eardrum pliable, waterproofs ear, kills bacteria, coats hairs

126
Q

Mammary Glands

A

Location:
- Develop in female pregnancy
- Stay throughout breast feeding

Function:
- Modified apocrine sweat glands – produce milk

127
Q

Burns

A

Causes:
- Fire, chemical spills, hot bath water, sunlight, radiation, electric shocks, chemical

Fatalities:
- Fluid loss, infection, toxic effects of the dead skin

Eschar:
- Burned, dead tissue
- Food for bacteria

128
Q

First-Degree Burn

A

Factors:
- Only damage epidermis
- Redness, slight edema or swelling, some pain

Healing:
- Heal in a few days without help
- Most sunburns fall into this

129
Q

Second-Degree Burn

A

Factors:
- Involves dermis and part of epidermis
- Leaves a chunk of dermis intact
- Red, tan, white, blistered and painful

Healing:
- Weeks or months to heal – larger area

130
Q

Third-Degree Burn

A

Leading cause of accidental death – full thickness burns

Factors:
- Destroy epidermis, all of the dermis, some of the subcutaneous tissue

Healing:
- Can only heal from the edges – large areas often need skin grafts