Lecture 9 (Synaptic Transmission)

Question 1

Neuromuscular Junction

Answer 1

• synapse between somatic motor neuron + muscle fiber(skeletal muscle cell)
• 1 muscle fiber = 1 synapse
• SMN; release Ach -> acts on nicotinic AChR’s
• Action terminate: Acetylcholinesterase

Question 2

End Plate Potential

Answer 2

• excitatory postsynaptic potential from ACh release -> open nonselective cation channel
• Mini End Plate Potential = 1 vesicle release to EPSP

Question 3

High Safety Factor

Answer 3

• always well above threshold -> act pot
• Present in end plate potential

Question 4

Myasthenia Gravia

Answer 4

• autoimmune disorder
• antibody -> destroy ACh receptors
• treated w/ acetylcholinesterase inhib

Question 5

Spatial Summation

Answer 5

• from diff sources grad pot adds -> act pot

Question 6

Temporal Summation

Answer 6

• graded pot in close time frame

Question 7

Glutamate

Answer 7

• main excitatory NT in CNS

Question 8

GABA

Answer 8

• main inhib NT in CNS

Question 9

Diffuse Neuromodulatory Systems

Answer 9

• neurons release Serotonin + Norepinephrine
• use GPCR’s
  affect mood + behaior
• inhibit reuptake = SSRI’s + SNRI