Lecture 10(Long Term Potentiation)

Question 1

Synaptic Plasticity

Answer 1

• change in strength of conn -
• basis for learning + memory

Question 2

Memory

Answer 2

• Short Term
• Working
  
  • attention + Prefrontal cortex
• Long Term
  
  • Consolidation
    
    • ST -> LT
  • Hippocampus

Question 3

HM (Patient)

Answer 3

• bilateral damage to hippocampus
• severe anterograde amnesia
• declarative memory affeted

Question 4

Declarative Memory

Answer 4

• Part of long term memory
• for facts, places, events
  
  • hippocampus

Question 5

Procedural Memory

Answer 5

• for motor skills

Question 6

LTP (Long Term Potentiation)

Answer 6

• long term enhancement of synaptic strength
• stimulate pathway w/ frequency -> strong depol post synaptic cell
• Specific
  
  • to synapse
• Assosiation
  
  • if other synapse weakly stim -> strengthed
• Can be induced
  
  • pair presynaptic stim w/ post syn depol induced

Question 7

Glutamate Receptors

Answer 7

• Iontropic
• AMPA
  
  • ligand gated ion ch -> Na+
• NMDA
  
  • blocked by Mg++
  • req glut binding + strong depol post syn to open
  • open -> Ca++ entry -> stronger synapse by more AMPA receptors