Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Oral Rad Path Midterm 2 > Lecture 9 - Oral Non-Squamous Malignancies > Flashcards

Lecture 9 - Oral Non-Squamous Malignancies Flashcards

1
Q

Leukemia

A

Originates in bone marrow

Myeloid (affects RBC precursor)
Lymphoid (affects Lymphotic precursor)
Acute or Chronic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Leukemia Diagnosis

A

Via peripheral blood and bone marrow biopsy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Leukemia Radiographic Appearance

A

Teeth floating in air

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Leukemia Systemic Findings

A 
Hepatosplenomegaly
Lymphadenopathy
Thrombocytopenia
Anemias
Fever
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Leukemia Oral Manifestations

A

Oral ulceration
Candidiasis
Gingival hyperplasia (“boggy”)
Gingival hemorrhage (platelets <10,000)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Leukemia Histologic Findings

A

Monotonous proliferation of poorly differentiated cells (RBC or WBC precursors)
Abnormal mitosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Hodgkin’s Lymphoma

A

Malignancy of lymph nodes

Oral lesions very RARE

Why are we learning this?

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Hodgkin’s Lymphoma Epidemiology

A

Bimodal: 15-30yr and >50yr

Males

75% cervical and supraclavicular nodes
5-10% axillary and mediastinal nodes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Hodgkin’s Lymphoma Systemic Findings

A 
Non-tender lymph node enlargement
Weight loss
Fever
Night sweats
General pruritis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Hodgkin’s Lymphoma Histologic Findings

A

Reed-Sternberg cells (giant, multi-nucleated cells with prominent nucleoli)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Non-Hodgkin’s Lymphoma

A

Malignancy of lymph nodes

Oral lesions most common in B-cell origin

Adults

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Non-Hodgkin’s Lymphoma Oral Manifestations

A

Soft tissue lesions:
-Non-tender, diffuse, “boggy” swelling in buccal vestibule, gingiva, and posterior hard palate

Bone lesions:

  • Vague pain
  • Parasthesias
  • Ill-defined radiolucencies
  • Bony expansion with cortical perforation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Non-Hodgkin’s Lymphoma

A

Infiltrative, monotonous proliferation of poorly differentiated lymphocytic cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Burkitt’s Lymphoma

A

Undifferentiated B-cell lymphoma

Associated with EBV

t(8;14)

Good prognosis with chemotheraphy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Osteosarcoma Oral Manifestations

A 
Tooth mobility and root resorption
Swelling
Pain
Parasthesia
Nasal obstruction
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Osteosarcoma Radiographic Findings

A
  • Loss of lamina dura
  • Asymmetric widening of PDL
  • Sclerotic, sunburst bone production on lesion surface
17
Q

Burkitt’s Lymphoma Oral Manifestations

A

Tooth mobility

Radiographic:

  • Teeth floating in air
  • Ill-defined borders
  • Patchy loss of lamina dura
18
Q

Burkitt’s Lymphoma Systemic Findings

A

Facial swelling

Proptosis

19
Q

Burkitt’s Lymphoma Histologic Findings

A

“Starry sky” (macrophages in lesional tissue)
Small, hyperchromatic non-cleaved B-cells
High mitotic rate

20
Q

Burkitt’s Lymphoma Epidemiology

A

Africa:

  • 50-70% in jaw
  • Kids
  • Males
  • EBV

America:

  • Abdominal lesions
  • 15-30% EBV
  • 40% of lymphomas in kids
21
Q

Osteosarcoma Epidemiology

A

7% in jaw
20-30yo
Males
Mandible

Common in elderly with Paget’s Disease

22
Q

Osteosarcoma Treatment

A

Surgical excision
Radiation
Chemo

30-50% 5yr survival

23
Q

Chondrosarcoma

A

<1% in head and neck

33yo
Male
Maxilla

Surgical excision, poor prognosis

24
Q

Chondrosarcoma Oral Manifestations

A

Painless swelling
Loosening of teeth, root resorption
Nasal obstruction/epistaxis

Histo - “cohabitating lacunae”

Rad - cortical penetration in sun-burst pattern

25
Q

Ewing Sarcoma

A

<20yo
White males
Mandible

Confirm diagnosis with CD99

26
Q

Ewing Sarcoma Presentation

A

Fever
Leukocytosis

Painful swelling
Paresthesia
Loose teeth, teeth “floating in air”

Histo - small, round blue cell tumor with pick necrosis b/t sheets of blue cells

27
Q

Multiple Myeloma

A

Clonal plasma cell proliferation
t(4;14)

Older black men

28
Q

Multiple Myeloma Systemic Findings

A 
Bone pain, pathologic fracture
Petechial hemorrhage
Myelophthisic anemia
Fever
Amyloidosis
Kidney failure
Radiolucent "punched out" bone lesions
29
Q

Multiple Myeloma Oral Findings

A

Amyloid deposition in tongue

Radiolucent “punched out” bone lesions

30
Q

Melanoma

A

1 in 2million people have oral mucosal melanomas each year in the US

50-70yo

Surgery, lymph node removal, hemimaxillectomy if bone involvement

4-20% 5 year survival

31
Q

Melanoma Oral Manifestations

A 
Brown/black macule, color variation
Irregular borders, asymmetric
Favors hard palate and gingiva
May be ulcerated
>6mm
32
Q

Salivary Gland Malignancy

A

Older patients

Slow-growing swelling
Weakness or paresthesia if nerve involvement

33
Q

Metastases to Oral Cavity

A
  1. Breast
  2. Lung
  3. GI
  4. Thyroid
  5. Prostate
  6. Kidney
34
Q

Nasopharyngeal Carcinoma

A

Most common in Asia, Africa, Pacific Rim
Middle age
Males

Radiation
Chemo

35
Q

Nasopharyngeal Carcinoma Presentation

A

Nasal cavity mass
Obstruction
Dysconjugate gaze
Mets to cervical lymph nodes

36
Q

Rhabdymyosarcoma

A

Skeletal muscle
Children

Mucosa looks normal

Histo - hot pink cytoplasm, trabecular fibrous connective tissue with floating cells

Oral Rad Path Midterm 2 (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions