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Oral Rad Path Midterm 2 > Lecture 1 - Benign Non-Odontogenic Tumors of the Jaw > Flashcards

Lecture 1 - Benign Non-Odontogenic Tumors of the Jaw Flashcards

1
Q

Giant Cell Lesions

A 
Central Giant Cell Granuloma (CGCG)
Central Giant Cell Tumor
Cherubism
Aneurysmal Bone Cyst
Brown Tumor
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2
Q

Pseudocysts

A

Traumatic Bone Cyst (Simple Bone Cyst)

Stafne Bone Cyst

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3
Q

Bony and Cartilaginous Tumors

A

Tori & Exostoses
Osteoma
Osteoblastoma
Osteoid Osteoma

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4
Q

Randos

A

Central Vascular Malformation
Desmoplastic Fibroma
Langerhans Cell Histiocytosis

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5
Q

Central Giant Cell Granuloma Pathology

A

Not actually a granuloma
Central GCG - intraosseous
Peripheral GCG - soft tissue

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6
Q

CGCG Clinical Appearance

A

2 types - Aggressive & Non-aggressive
F>M
<30yr
70% anterior mandible

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7
Q

CGCG Clinical Symptoms

A

Non-Aggressive:

  • More common
  • Asymptomatic
  • Expansion
  • No resorption

Aggressive:

  • Pain
  • Rapid growth
  • High recurrance
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8
Q

CGCG Radiographic Appearance

A

Well defined radiolucency
Uni-locular or multi-locular
Non-corticated

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9
Q

CGCG Histologic Appearance

A

Multi-nucleated giant cells
Ovoid-spindle mesenchymal cells
Extravasated RBCs w/ hemosiderin deposits

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10
Q

CGCG Treatment

A

Curettage
~20% recurrance

Aggressive tumors treat with:

  • corticosteroids
  • calcitonin
  • interferon alpha 2a
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11
Q

CGCG Ddx

A

On radiograph:

  • ameloblastoma
  • KOT

On histo:

  • brown tumor of hyperparathyroidism
  • cherubism
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12
Q

Central Giant Cell Tumor Pathology

A

Benign, but more aggressive than GCG

Often in long bones

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13
Q

Central Giant Cell Tumor Histologic Appearance

A

Hypercellular

Multi-nucleated giant cells

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14
Q

Cherubism Pathology

A

Rare
Developmental
Autosomal Dominant heritance

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15
Q

Cherubism Clinical Appearance

A

Age 2-5
Bilateral swelling in post. mandible
Regress in puberty

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16
Q

Cherubism Radiographic Appearance

A

Bilateral, multi-locular lucency at angle and ramus

rare: ribs and humerus

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17
Q

Cherubism Histologic Appearnce

A

Multi-nucleated giant cells
Vascularized connective tissue
Eosinophilic cuffing (deposited around blood vessels)

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18
Q

Cherubism Treatment

A

Wait for regression

Sometimes surgical intervention

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19
Q

Aneurysmal Bone Cyst Pathology

A

Not a cyst - not lined with epithelium

Blood-soaked sponge appearance

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20
Q

Aneurysmal Bone Cyst Clinical Appearance

A

F>M
<20yr
2:1 mandible

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21
Q

Aneurysmal Bone Cyst Radiographic Appearance

A

Expansile
Uni- or multi-locular
Tooth displacement and/or reabsorption

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22
Q

Aneurysmal Bone Cyst Histologic Appearance

A

Blood filled cystic spaces
No epithelial lining
Walls contain multi-nucleated giant cells
Osteoid production

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23
Q

Aneurysmal Bone Cyst Treatment

A

Excision/curettage

26% recurrance

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24
Q

Brown Tumor Pathology

A

Can by caused by primary hyperparathyroidism

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25
Q

Brown Tumor Radiographic Appearance

A

Mixed lucent and opaque

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26
Q

Brown Tumor Histologic Appearance

A

Multi-nucleated giant cells

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27
Q

Traumatic Bone Cyst Clinical Appearance

A

M>F
10-20 yr
Unilateral
Mandibular

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28
Q

Traumatic Bone Cyst Clinical Symptoms

A

Asymptomatic

29
Q

Traumatic Bone Cyst Radiographic Appearance

A

Well-circumscribed lucency

Scalloping at roots

30
Q

Traumatic Bone Cyst Histologic Appearance

A

No epithelial lining

Lumen is empty or filled with blood or fluid

31
Q

Traumatic Bone Cyst Treatment

A

Evacuate contents

32
Q

Stafne Bone Cyst Pathology

A

Concavity of cortical bone on lingual surface

Developmental defect with salivary gland

33
Q

Stafne Bone Cyst Clinical Appearance

A

M>F

0.3% of population

34
Q

Stafne Bone Cyst Radiographic Appearance

A

Lucency BELOW mandibular canal b/t molars and angle
Well-circumscribed
Notch in inferior border of mandible
Unilateral

35
Q

Stafne Bone Cyst Histologic Appearance

A

Salivary gland tissue

Some have no tissue

36
Q

Stafne Bone Cyst Treatment

37
Q

Tori and Exostoses Pathology

A

Bony protruberance

38
Q

Tori and Exostoses Clinical Appearance

A

Bilateral or midline

39
Q

Tori and Exostoses Histologic Appearance

A

Lamellar bone (normal)

40
Q

Osteoma Pathology

A

Benign tumor of compact bone

41
Q

Osteoma Clinical Appearance

A

Periosteal - at surface
Endosteal - within the bone
Young adults

42
Q

Osteoma Clinical Symptoms

A

Painless swelling

43
Q

Osteoma Radiographic Appearance

A

Circumscribed

Sclerotic

44
Q

Osteoma Histologic Appearance

A

Lamellar bone

Some marrow

45
Q

Osteoma Treatment

A

Excision of symptomatic lesions

46
Q

Gardner Syndrome

A

Autosomal Dominant
Multiple osteomas (skull, sinus, mandible)
Supernumerary teeth
Skin/soft tissue epidermoid cysts
Desmoid tumors
Thyroid carcinoma
Colonic polyps -> adenocarcinoma (prophylactic colectomy)

47
Q

Osteoblastoma Pathology

A

Benign tumor of osteoblasts

Rare

48
Q

Osteoblastoma Clinical Appearance

A

<30yr

Vertebrae, sacrum, calvarium, long bones, post. mandible

49
Q

Osteoblastoma Clinical Symptoms

A

Pain (unrelieved w/ aspirin)

50
Q

Osteoblastoma Radiographic Appearance

A

Radiolucent

patchy mineralization

51
Q

Osteoblastoma Histologic Appearance

A

Like cementoblastoma

Mineralized trabeculae rimmed by osteoblasts
Loose, fibrous connective tissue
Radiating spicules

52
Q

Osteoblastoma Treatment

53
Q

Osteoid Osteoma Clinical Appearance

A

<2cm

Femur, tibia, post. mandible

54
Q

Osteoid Osteoma Clinical Symptoms

A

Nocturnal pain (relieved w/ aspirin)

55
Q

Central Vascular Malformation Pathology

A

Benign vascular lesion

56
Q

Central Vascular Malformation Clinical Symptoms

A

Painless Swelling

57
Q

Central Vascular Malformation Radiographic Appearance

A 
Lucency
Radiating opacities (sun burst)
58
Q

Central Vascular Malformation Histologic Appearance

A

Proliferation of capillaries
Endothelial cells
Contains blood

59
Q

Central Vascular Malformation Treatment

A

Surgery +/- embolization

Sclerosing agents

60
Q

Desmoplastic Fibroma Clinical Appearance

A

<30 yr
Mandible
Rare

61
Q

Desmoplastic Fibroma Clinical Symptoms

A

Painless swelling

62
Q

Desmoplastic Fibroma Radiographic Appearance

A

Unilocular
Perforate cortex/soft tissue
Root resorption

63
Q

Desmoplastic Fibroma Histologic Appearance

A

Elongated fibroblasts

Dense collagen bands

64
Q

Desmoplastic Fibroma Treatment

A

Resection

High recurrance

65
Q

Langerhans Cell Histiocytosis Pathology

A

Proliferation of Langerhans cells (dendritic mononuclear cells), eos, lymph, plasma cells, giant cells

66
Q

Langerhans Cell Histiocytosis Clinical Appearance

A

M>F
<15 yr

  1. Eosinophilic granuloma of bone (bone lesions)
  2. Chronic disseminated histiocytosis (bone, skin, visceral)
  3. Acute disseminated histiocytosis (cutaneous, visceral, marrow, infants)
67
Q

Langerhans Cell Histiocytosis Radiographic Appearance

A

NON-corticated lucencies

Teeth “floating in air”

68
Q

Langerhans Cell Histiocytosis Histologic Appearance

A

Large, pale, mononuclear cells
Birbeck granules
Eosinophils

69
Q

Langerhans Cell Histiocytosis Treatment

A

Surgery
Radiation
Chemotherapy

Better prognosis in older pts w/o visceral involvement.

Oral Rad Path Midterm 2 (11 decks)

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