lecture 9 - bleeding disorders Flashcards
1
Q
How is von Willebrand factor activated by endothelial damage?
A
Shear forces of blood flow on the endothelium cause vWF to uncoil
2
Q
How is vWF involved in the coagulation cascade?
A
It binds to and protects FVIII from degradation - thus involved in the intrinsic pathway
3
Q
What is the pattern of inheritance of von Willebrand disease?
A
Autosomal dominant
4
Q
What are the ways in which the coagulation process and platelet activation are connected?
A
Coagulation factors work typically on the surface of activated platelets, fibrinogen and thombin both help in the formation of the platelet plug
5
Q
What is the function of heparin in anti-coagulation?
A
It enhances the action of antithrombin, preventing clotting from occuring.
