lecture 9 Flashcards

1
Q

what are the 5 major types of connective tissue?

A
  • bone
  • tendon
  • cartilage
  • derma (skin)
  • fascia
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2
Q

what are some examples of specialised connective tissue?

A
  • umbilical cord
  • kidney cortex
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3
Q

what do connective tissues have in common?

A
  • relatively few cells
  • lots of extracellular material/matrix
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4
Q

what are the fibres found ?

A
  • elastin and collagen
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5
Q

how are they arranged?

A
  • in parallel or crisscrossed meshwork
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6
Q

what are connective tissue characteristics relative to?

A
  • fibrillar proteins
  • proportions of collagen and proteoglycans
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7
Q

what are proteoglycans?

A
  • specialised form of glycoprotein
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8
Q

what are the 3 main types of cartilage?

A
  • hyaline (in joints)
  • fibrous (annulus fibrosus, repair)
  • elastic (elastin, ear lobes, epiglottis)
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9
Q

what is hyaline cartilage?

A
  • covers bone articulating surfaces (joints)
  • forms distal ends of ribs
  • forms cartilaginous plates of nasal septum, larynx, trachea and bronchi
  • firm and flexible
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10
Q

what is the flexibility of hyaline cartilage due to?

A
  • proteoglycan content
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11
Q

what is the rigidity and tensile strength of hyaline cartilage due to?

A
  • collagen content
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12
Q

what is the structure of the synovial joint?

A
  • 2 bones
  • capsule containing synovial fluid (lubrication of joint)
  • cartilage layer on surface
  • perichondrium on top (skin thin)
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13
Q

how does the cartilage gain nutrients?

A
  • synovial fluid as in contact with blood
  • up through subchodral bone
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14
Q

what are the characteristics of cartilage?

A
  • no nerve supply
  • not innervated with blood or neves
  • immune privileged as no blood supply (no surveillance from immune system)
  • low chondrocyte nutrient supply
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15
Q

what is found in an immobilised joint?

A
  • hydroxyproline increased in blood
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16
Q

what is the structure of hyaline cartilage?

A
  • collagen criss cross matrix
  • spaces filled with proteoglycans (neg charged)
  • lots of water held
  • net structure used to minimise swelling pressure
17
Q

what gives proteoglycans its negative charge?

A
  • carboxylic acid groups
  • sulphate groups
18
Q

what is the composition of collagen?

A
  • 30% glycine
  • 30% proline/hydroxyproline
  • hydroxylysine
  • made of many tropocollagen molecules aggregated together so insoluble
19
Q

what is tropocollagen?

A
  • type 2 trans helix
  • has hydrogen bonds holding together
  • regular composition of glycine-a.a-a.a-glycine etc.
20
Q

what is the composition of scurvy?

A
  • proline + vitamin C forms HO-proline
  • without cant form hydroxylproline
21
Q

what is osteoarthritis?

A
  • stiffening and pain in joints
22
Q

what is osteoarthritis caused by?

A
  • protective cartilage on bones breaking down
23
Q

what are current treatments of osteoarthritis?

A
  • focused on symptomatic release
  • no medical intervention yet to control progression of disease
24
Q

what crosstalk causes osteoarthritis?

A
  • cartilage and subchondral bone
  • deterioration of one causes damage to other