lecture 8? therapy in lung patients with CLAD Flashcards
1
Q
what occurs with increasing levels of neutrophils?
A
- packed with elastase and collagenase
- can digest through the airway tissue
- results in scar collagen being left in airways
- epithelial fibrosis and airway limitation
2
Q
what are the advantages of research with lung transplants?
A
- build lung function
- samples easily taken
3
Q
how does social function change years after a lung transplant?
A
- lower social function
- equivalent to people suffering chronic illnesses
4
Q
what was found in hydroxychloroquine?
A
- has effect on epithelial cells / cell lines
5
Q
what is total lymphoid irradiation?
A
- type of immunosuppression for patients undergoing transplantation that have refractory allograft rejection during standard immunosuppressive therapy
6
Q
what is most injury after lung transplant associated with?
A
- low immunity
7
Q
what is fundoplication?
A
- tightens the lower oesophageal sphincter by wrapping round
- causes less reflux back up oesophagus
8
Q
what occurs if fundoplication wrapped round too tight?
A
- food wont be able to move down oesophagus
9
Q
did fundoplication improve freedom from BOS?
A
- yes
- took longer for patients to gain BOS after the surgery but lots still gained
10
Q
what is the issue with this treatment?
A
- if cant tolerate anaesthetic
11
Q
what is azithromycin ?
A
- used as anti-malarial therapy
- already had safety benefits / experiments
12
Q
how does baseline change with administration of azithromycin?
A
- fluctuating values
- people still deteriorate but can gain lung function
13
Q
when are patients classed as responders?
A
- when improvement was 10% or higher
- compared to baseline values at start of azithromycin therapy
14
Q
what were the results from induction therapy with azithromycin in BOS?
A
- not much effect on overall survival
- helps but means on long term antibiotics
15
Q
what was the effect of azithromycin in CF?
A
- 12/14 infected with nontuberculous mycobacteria (NTM)
- proves link between NTM and CF
