Lecture 8D - Bordetella pertussis and parapertussis (Dr. Daniels)

Question 1

Describe Bordatella pertussis and parapertussies

Answer 1

gram negative
rod
obligate aerobe
VERY CONTAGIOUS

Question 2

What disease does it cause?

Answer 2

Whooping cough

-potentially fatal in infants

Question 3

Attack rate

Answer 3

90% (9/10 ppl in household will get it)

Question 4

How many ppl can 1 person infect?

Answer 4

12-15

Question 5

Who is infected/carriers?

Answer 5

Adults

Question 6

Where colonization happens

Answer 6

nasopharynx, just like pneumococcus in children

Question 7

Ciliary adherence in trachea/bronchi via…

Answer 7

1. filamentous hemagglutinin (Fha)
2. Pili (fimbriae)
3. pertactin protein

Question 8

How do they damage

Answer 8

increase cAMP
   -decrease neutrophil fxn
   -increase capillary permeability leads to edema
LPS causes inflammation
pertussis toxin

Question 9

does B. pertusses have pertusses toxin?

Answer 9

Yes

Question 10

Does p. parapertussis have pertussis toxin?

Answer 10

No

Question 11

What are the stages of whooping cough?

Answer 11

1. Catarrhal stage (CONTAGIOUS runny nose)
   
   • 1-2 weeks
2. Paroxysmal Stage (coughing)
   
   • 1-6 weeks
3. Convalescent stage (recovery)
   
   • 2-3 weeks

Question 12

Diagnosis of whooping cough

Answer 12

deep nasal swab (culture)
nasal flush (PCR)

Question 13

When is whooping cough diagnosable

Answer 13

less than 3 weeks of cough onset (paroxymal stage) b/c few organisms are present after that point.

Question 14

How to prevent whooping cough

Answer 14

dTaP vaccine if less than 11 years old.
Tdap vaccine if 11-64 or pregnant
-this one has lower doses of diptheria & pertussis components

Question 15

What do dTaP and Tdap contain?

Answer 15

tetanus, Diphtheria, and Pertussis vaccines

Question 16

What is bordatella bronchiseptica?

Answer 16

kennel cough

can infect HIV+, chemo patients, etc. but rare