Lecture 8 (Travel med+military medicine)- Exam 4 Flashcards
Travel Medicine- Occupational Specialty
* Travel medicine is devoted to what?
* It is an interdisciplinary specialty concerned with what? (3)
Travel medicine is devoted to the health of travelers who visit foreign countries.
It is an interdisciplinary specialty concerned with:
* Prevention of infectious diseases during travel.
* Personal safety of travelers.
* Avoidance of environmental risks.
Travel Medicine- Occupational Specialty
* Where will patient present?
However, most patients will present to primary care pre-travel and emergency department post-travel.
Most common diseases in returning US Travelers
* Most common are what?
* What is the most potentially life threatening?
- Most common are travelers’ diarrhea and respiratory infections.
- Most potentially life-threatening is malaria.
Most common diseases in returning US Travelers
* What are 5 common diseases?
- Diarrheal Disease
- Malaria
- Dengue/Zika/Chikungunya
- Tuberculosis
- Typhoid
What are the less common diseases? (4)
- Yellow Fever
- Japanese Encephalitis
- Hepatitis A
- Meningococcal Meningitis
Fever in the Returning Traveler
* According to the World Health Organization, the most common diseases in Ghana include those endemic to sub-Saharan African countries, are what?
particularlymalaria, cholera, typhoid, pulmonary tuberculosis, anthrax, pertussis, tetanus, chicken pox, yellow fever, measles, infectious hepatitis, trachoma, HIV and schistosomiasis
Fever in the Returning Traveler
* Returned travelers with fever should undergo at least the following investigations: (4)
- CBC, Liver Enzymes, Electrolytes, Renal Function
- Malaria Smears at least three times over 24-48 hours.
- Blood cultures x 2
- UA
Returned travelers with fever should undergo at least the following investigations:
* You need to cite what?
* The febrile traveler to a malaria-endemic area should be considered to have what?
- Cite the travel history on the lab order.
- The febrile traveler to a malaria-endemic area should be considered to have malaria until proven otherwise.
Where are the malaria endemic countries?
Malaria-
* what is the process of infection?
- Parasite (Plasmodium) infects a mosquito that spreads to humans through mosquito saliva.
- The parasite enters the liver cells and replicates.
- The liver cell erupts, and the parasites enter red blood cells.
- In the RBC, they hide from the immune system, continue to replicate, and become sticky.
- The RBC bursts, releasing parasites.
Malaria-
* What is the type of mosquito?
Anopheles (Pregnant)
What are the 5 Type of Plasmodium Parasites cause Malaria?
- Plasmodium falciparum (or P. falciparum)- The most prevalent and causes the majority of severe disease and deaths
- Plasmodium vivax (or P. vivax)- the main cause of relapsing malaria; prevalent in SE Asia and Latin America
- Plasmodium ovale (or P. ovale)
- Plasmodium knowlesi (or P. knowlesi)
- Plasmodium malariae (or P. malariae)
Malaria
* What are the areas of concern? (3)
* Who is at risk?(2)
- Area of Concern: Africa, South/Central America, and Southeast Asia
- At Risk (Epidemiology): In endemic countries, those at risk are young children and pregnant women.
Malaria
* Who is at high risk?
* For this reason, it is essential to consider malaria in who?
* Vaccine?
- Travelers to malarious areas generally have had no previous exposure to malaria parasites or have lost their immunity if they left the endemic area; they are at high risk for severe disease if infected withPlasmodium falciparum.
- For this reason, it is essential to consider malaria in all febrile patients with a history of travel to malarious areas.
- No vaccine available
Malaria
* What are the sxs/presentation?
- Fever. This is the most common symptom. The fever occurs in paroxysms/cyclical.
- Chills.
- Headache.
- Sweats.
- Fatigue.
- Nausea and vomiting.
- Body aches.
- Generally feeling sick.
- Jaundice +/-
Malaria
* how do you dx it? (3)
- High Index of Suspicion
- Blood smears and rapid tests available
- Presumptive diagnosis
Malaria
* What is the treatment of uncomplicated disease with non-falciparum malaria?
Chloroquine (Mefloquine) (if not from an area that was Chloroquine resistant) or Artemisinin
Malaria
* What is the treatment of Severe Disease with P. Falciparum malaria or mild disease with P. Falciparum (in the United States)?
- Administer oral antimalarial therapywhile obtaining IV artesunate. If oral therapy is not tolerated, consider administration via nasogastric tube or following an antiemetic.
- Make a referral to infectious disease.
Malaria- Best Defense is Offense
* What is the prevention?
* Choice depends on what?
- Options for chemoprophylaxis include atovaquone-proguanil, mefloquine, doxycycline, and tafenoquine; all four agents are highly efficacious for prevention of malaria.
- Choice depends on where the traveler is going and local resistance rates.
Malaria- Best Defense is Offense
* Avoid outdoor exposure when?
* Wear what? (2)
* Sleep with what?
* Stay in what?
- Avoiding outdoor exposure between dusk and dawn (when Anopheles mosquitoes feed)
- Wearing clothing that reduces the amount of exposed skin
- Wearing insect repellant (as described below)
- Sleeping within bed nets treated with insecticide (eg,permethrin)
- Staying in well-screened or air-conditioned rooms
What are the areas with zika?
Zika/Dengue/Chikungunya
* What type of virus?
* Transimitted how?
* What is the mosquito?
* The virus can live in what?
- Flavavirus
- All are RNA Viruses transmitted by a mosquito.
- Mosquito: Aedes- feeds in the daytime.
- The virus can live in the blood, urine, semen, CSF, saliva, breast milk, and amniotic fluid.
Zika/Dengue/Chikungunya
* Early phase is diagnose with what test? What happens if positive or negative?
Early phase- diagnose with PCR- if it’s positive- then that is positive but if it is negative- does not rule it out because the virus may have cleared because the body has created antibiodies- so then you have to do serology testing to look for IgM.
Zika/Dengue/Chikungunya
* What is the txt?
* Pregnancy?
Treatment- Supportive
* Tylenol- Not aspirin
DO NOT GET PREGNANT- FEMALE FOR AT LEAST 8 WEEKS AND MALES FOR AT LEAST SIX MONTHS
Yellow Fever- Hemorrhagic Fever
* What type of virus?
* Vaccine?
* Where are areas?
* Spread by what?
- Flavavirus RNA Virus
- Vaccine is good for life but not 100% effective.
- Sub-Saharan Africa, South America
- Spread by mosquitos (found in monkeys and humans are highly susceptible). Aedes Mosquito- feeds during the day.
Yellow Fever- Hemorrhagic Fever
* How is it spread?
- Injected through mosquito saliva and replication begins at site of inoculation.
- Spreads through lymphatics then reaches the bloodstream.
- Large amounts of virus are then seeded in the liver, spleen and lymph nodes where is continues to replicate and release.
Yellow Fever- Hemorrhagic Fever
* What are mild symptoms?
* What are are the severe symptoms?
- Mild symptoms:Fever, chills, headache, nausea, vomiting, muscle pain, and loss of appetite
- Severe symptoms:Jaundice, bleeding, shock, organ failure, dark urine, stomach pain, and vomiting
Yellow Fever- Hemorrhagic Fever
* What are the fetal symptoms? (4)
* Dx with what?
* What is the treatment?
* Who is at risk of severe sxs?
- Fatal symptoms:Delirium, seizures, coma, and death
- Dx’s with PCR
- Treatment- Supportive
- At risk of severe symptoms: Older, white men
Japanese Encephalitis
* What are the areas of concern?
* What type of virus?
* How does it spread?
* Most at risk are what?
- Area of Concern- Asia/Western Pacific
- Flavavirus RNA Virus
- Mosquito borne (pigs are infected). Humans are dead end hosts as they do not develop high levels of the virus.
- Most at-risk are in rural areas for longer duration of travel.
Japanese Encephalitis
* the United States Advisory Committee on Immunization Practices (ACIP) which recommends what?
the United States Advisory Committee on Immunization Practices (ACIP) which recommends JE vaccine for individuals moving to a JE-endemic country to take up residence, longer-term (eg, ≥1 month) travelers to JE-endemic areas, and frequent travelers to JE-endemic areas
Japanese Encephalitis
* Most hunam JEV infections are what?
* Fewer than 1% of JEV infections result in what?
* However, when neurologic disease does occur, it is usually what/
- Most human JEV infections are asymptomatic or cause a nonspecific febrile illness.
- Fewer than 1 percent of JEV infections result in symptomatic neuroinvasive disease.
- However, when neurologic disease does occur, it is usually very severe with a high case-fatality rate; among survivors, neurological sequelae are common.
Japanese Encephalitis
* What is the treatment?
* All travelers to JEV-endemic countries should be advised on what?
- Treatment- supportive
- All travelers to JEV-endemic countries should be advised on measures to prevent JE, and JE should be considered among the differential diagnoses for patients with suspected neurological infection who have returned from recent travel in a JEV-endemic country in Asia or the Western Pacific region.
Japanese Encephalitis
* Dx how?
* Should contact who?
* What is the txt?
* What is the mortality rate?
- Diagnosed by antibodies.
- Should contact the CDC and refer to ID
- Treatment- Supportive care
- Mortality in hospitalized patients is 20-30%.
Japanese Encephalitis
* When should you get a vaccine?
Longer duration of travel
* ●Travel during the JEV transmission season
* ●Spending time in rural areas
* ●Participating in extensive outdoor activities
* ●Staying in an accommodation without air conditioning, screens, or bed nets
Japanese Encephalitis
* However, if a person received the vaccine, but still came home with a fever, stiff neck, and headache, the next step
However, if a person received the vaccine, but still came home with a fever, stiff neck, and headache, the next step would be a lumbar puncture.
Typhoid Fever
* The organism classically responsible for the enteric fever syndrome is what?
* How do they infect the body?
- The organism classically responsible for the enteric fever syndrome is Salmonella enterica serotype Typhi
- These organisms are ingested and survive exposure to gastric acid before gaining access to the small bowel, where they penetrate the epithelium, enter the lymphoid tissue, and disseminate via the lymphatic or hematogenous route.
Typhoid Fever
* What is the only organism that can disease in humans?
* Vaccine?
- S.enterica serotype Typhi causes disease only in humans; it has no known animal reservoir. Infection therefore implies direct contact with an infected individual or indirect contact via contaminated food or water.
- Vaccine is available but is not 100% effective.
Typhoid Fever
* When do the onset of sxs occur?
* Majority of patients present with what?
* What happens on the 2nd week of illness?
- Onset of symptoms- 5-21 Days after exposure.
- Majority of patients present with abdominal pain, fever, and chills. +/- Diarrhea or Constipation
- 2nd Week of illness: rose spots” (faint salmon-colored macules on the trunk and abdomen) may be seen. (salmon colored rash)
Typhoid Fever
* What are the sxs of 3rd week?
* What happens to the sxs?
- 3rd week of illness, hepatosplenomegaly, intestinal bleeding, and perforation due to ileocecal lymphatic hyperplasia of the Peyer’s patches may occur, together with secondary bacteremia and peritonitis.
- In the absence of acute complications or death from overwhelming sepsis, symptoms gradually resolve over weeks to months.
Typhoid Fever
* How do you dx and tx it?
- Diagnosed by stool culture
- Treatment- Fluoroquinolone, Zithromax, or ceftriaxone
Typhoid Mary
* What does it mean to the a chronic carrier of salmonella?
Chronic Carriers of Salmonellacarriage is defined as excretion of the organism in stool or urine >12 months after acute infection.
Typhoid Mary
* Chronic carriers appear to reach an immunologic equilibrium in which what happens?
* Management of chronic carriage generally consists of what?
- Chronic carriers appear to reach an immunologic equilibrium in which they are chronically colonized (usually in the biliary tract) and may excrete many organisms but do not develop clinical disease.
- Management of chronic carriage generally consists of antimicrobial therapy. If eradication is not achieved with antimicrobial therapy, cholecystectomy may be warranted.
Hepatitis A
* Hep A is caused by what?
* HAV is usually transmitted by what?
- Hepatitis A infection is caused by the hepatitis A virus (HAV) Humans are the only known reservoir.
- HAV is usually transmitted by the fecal-oral route (either via person-to-person contact or consumption of contaminated food or water).
Hepatitis A
* HAV can remain infectious on hands for how long? food? surfaces?
* What has never been described?
- HAV can remain infectious on hands for several hours, on foods for several days, and on frozen foods, surfaces, and in feces for several months.
- Maternal-fetal transmission has not been described.