Lecture 8 - Neuronal migration

Question 1

how to see neurons in tangential and radial migration

Answer 1

label cells with GFP and use fluorescence imaging

Question 2

neuroepithelium is pseudostratified due to…

Answer 2

migration of mitotically dividing nuclei

Question 3

one cell thick neuroepithelium is made up of..

Answer 3

neuroepithelial cells

Question 4

interkinetic nuclear migration

Answer 4

where their nuclei of neuroepithelial cells move up and down, having the appearance if multiple layers

Question 5

neuroepithelial cells go through phases of the cell cycle

Answer 5

1. G1 = nuclei move up
2. G2 = nuclei move down
3. S phase = basal and division
4. M phase occurs at apical

Question 6

divisions of neuroepitheial cells

Answer 6

these are symmetrical and give rise to two daughter cells that have the same properties as parent cells. later on they divide asymmetrically

Question 7

what do neuroepithelial cells generate

Answer 7

radial glia and neuronal precursors

Question 8

radial glia

Answer 8

still capable of both asymmetric and symmetric division to carry on amplifying their numbers

Question 9

mature neurons accumulate time layers above ventricular zone

Answer 9

do this by radially migrating