Lecture 1 - intro to developmental neuro Flashcards
1
Q
progenitors
A
early cell types from which neurons are born
2
Q
cell division
A
- highly coordinated
- coordination of cells is what gets nerves generates and assembled at the right time and place
3
Q
regionalisation
A
where early cells are instructed to become a particular cell
4
Q
what governs cell differentiation?
A
- changes in gene expression, which dictates the properties
- depends on both extrinsic (signals) and intrinsic factors (transcription factors)
5
Q
extrinsic information
A
- received from cells surroundings
- ‘undecided’ cell receives chemical signals from a neighbour which alters the receiving cell.
- cell released a signal that binds to a receptor that binds to a receptor on another cell, changing its fate
6
Q
intrinsic information
A
- already in the cell and provides a ‘memory’ and ‘instruction’ for further fate-specification.
- daughter cells inherit fate-specifying molecules that are present in mother cell
7
Q
asymmetric distribution
A
fate-determining molecules can make daughter cells with different identities
8
Q
best way to characterise cells
A
in-situ hybridisation or the protein that is expressed with immunohistochemistry. can carry studies for loss or gain of functions done in cells/tissues
