Lecture 8 Flashcards
What are the 3 key properties of connective/support tissue
Tensile strength-collagen
elasticity- elastin
volume- ground substance
What are the classes if CT
Connective tissue proper(loose and dense), Cartilage, bone and blood
What are the subtypes of loose ct proper
Areolar, reticular and adipose
What are the subtypes of dense ct
Regular/parallel and irregular/non-parallel
What are the 2 aspects of CT
Cells and ecm
What is the precursor to the support cells in the CT
Mesenchyme
What are the 3 main components of the ECM
Ground substance, fibrillar proteins and adhesion
What does fibrillar proteins contribute to the ECM
Strength and elasticity (these are collagen and elastin)
What do adhesion proteins contribute to the ECM
Links everything in the ecm together(these are fibronectin and laminin)
Fibronectin attaches collagen to integrins and binds proteoglycans, cells and collagen together.
Laminin makes sheets that make the BM and assists hemidesmosomes in attaching epithelial cells to the BM with help of integrins. Also assists focal adhesions at attaching other types of cells to the bm
What are focal adhesions
How are integrins linked to bm
Theyre linked to the cytokeratin via an electron dense plaque and linked to the bm on the other side by anchoring on laminin filaments
Describe GAGs/ glycosaminoglycans
Long branched polysaccharide chains with hyaluronic acid being the most common one and largest. other gags connect to hyaluronic acid with core proteins this forms proteoglycans
theyre negatively charged and hydrophilic
What do proteoglycans and gags do for the ecm and what do they interact with
Form ground substance, provide volume and compression resistance.
they interact with each other, water and salts, collagen and other fibres and molecules
Describe collagen structure
The most abundant protein in the body, is formed out of a series of twisted fibres into triple helices making it appear striped in em. Theres 28 types of collagen with different amino acids making them.
type 1 makes up 90% of collagen, 2 makes cartilage, 4 bm
Describe elastin
Comprised of short segments that are covalently bound to each other for stretching and relaxation
