Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

SMP > Lecture 77 > Flashcards

Lecture 77 Flashcards

1
Q

Ligand Binding Domain

A

Low AA identity. Also involved in receptor dimerization, interaction with other proteins, and nuclear localization

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

DNA binding domain

A

High AA identity.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

How is AF-1 (transcriptional activation function 1) activated?

A

Phosphorylation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

How is AF-2 (transcriptional activation function 2) activated?

A

Ligand binding

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Name five types of type I nuclear receptors.

A 
Estrogen (ER)
Androgen (AR)
Glucocorticoid (GR)
Progesterone (PR)
Mineralocorticoid (MR)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Name seven types of type II nuclear receptors

A 
Thyroid hormone (TR)
Vitamin D (VDR)
Retinoic acid (RAR)
Retinoid X (RXR)
Peroxisome proliferator-activated (PPAR)
Liver X (LXR)
Farnesoid X (FXR)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the ligand for RXR?

A

9cisRA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the ligand for PPARa?

A

Fibrates

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the ligand for PPARg?

A

Glitazones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the ligand for PXR?

A

Xenobiotics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the ligand for LXR?

A

Oxysterols

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the ligand for FXR?

A

Bile Acids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the ligand for VDR?

A

1,25-dihydroxy vitamin D3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the ligand for RAR?

A

All-trans retinoic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are characteristics of Type I ligands?

A
  • All are derived from cholesterol
  • High specificity and affinity
  • pM to nM concentrations in serum
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are characteristics of Type II ligands?

A
  • Low specificity and affinity
  • “promiscuous”
  • present in uM to mM concentrations in serum
17
Q

How do NRs bind DNA?

A

Zinc finger motifs

SMP (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions