Lecture 76

Question 1

_______ is an antifungal that inhibits nucleic acid synth by acting as a pyrimidine analog. It is converted to 5-fluorouracil in fungi and competitively inhibits _______ synthase.

Answer 1

Flucytosine

Thymidylate synthase

Question 2

Amphotericin B is a Polyene that binds ______ in the fungal membrane. Nyastatin is in the same group of drugs/mech of action.

Answer 2

Ergosterol

Question 3

Echinocandins, all the “…fungins” inhibit fungal ____ ____ synthesis, by non-competitively inhibiting b-1,3-glucan synth.

Answer 3

Cell wall

Question 4

Tolnaftate and Terbinafine inhibit fungal ______ epoxidases, the enzyme involved in the rate limiting step of ______ synth.

Answer 4

Squalene

Ergosterol

Question 5

Griseofulvin disrupts the _____ spindle and binds to keratin.

Answer 5

Mitotic

Question 6

______ decreases blood levels of azoles by inducing their metabolization.

Answer 6

Rifampin