Lecture 7 Flashcards
What is the genome of herpesviruses?
double stranded linear DNA
Are herpesviruses enveloped on non-enveloped?
Herpes viruses are enveloped
Where does replication occur within herpesviruses?
replication is intranuclear
Describe the lifecycle of herpes:
- Gets into the cell
- Uncoats and then travels to the nucleus
- Replicative stages of mid-early and late
- They get their lipid from inside the cell itself – the lifecycle is all the same except for this element of it (ie. Not taking the cell membrane with them)
Describe the characteristics of Alphaherpesvirinae:
very fast in their reproduction leading to rapid destruction
of cell
Describe the characteristics of Betaherpesvirinae
much slower productive cycle meaning a longer time to . destroy
Describe the characteristics of Gammaherpesvirinae:
specific for the T cell and B cells
What is the basic structure of herpes genomes?
- Terminal repeat at each end
- Two major coding regions US and UL
- coding regions have a series of internal repeats
What are the two main means of transmission for Herpes Viruses?
- aerosol transmission
- direct transmission via mucous membranes
Where does the parasite hide during the latency phase?
- lives within the ganglia of the sensory neurons
How does the Herpes virus acquire its cell membrane?
It gets the cell membrane from within the cell itself
Where is Cercopithecine herpesvirus B naturally found and what is the impact should it infect humans?
Normally found within monkeys. Generally when it infects humans it will result in fatality
Where is human herpesvirus 1 found and what is its impact upon humans?
Very common within humans and it causes cold sores
What is the appearance of human herpes virus 2 and where does it normally infect?
Typically seen as lesions on the genitals:
Humans herpesvirus 3 is colloquially referred to as “chickenpox” if it were to come out of latency what condition would it cause?
shingles
What is the species that gallid herpesvirus 1 (ILT) normally infects and what is usually the cause of death?
- Normally infects chickens and pheasants
- Death normally occurs by occlusion the trachea due to haemorrhage
What types of cells does gallid herpesvirus 2 normally infect and what generally causes death?
Gallid herpesvirus 2 is generally associated with Marek’s disease. Occurs in chickens. Infects T-cells and B-cells and can be cancerous when it begins to invade other hosts
What are the common clinical signs observed from equine herpes virus 1?
neuropathy and abortion
What are the symptoms of suid herpesvirus one?
- high levels of abortion
- cattle often experience itching
What are the symptoms of Malignant Catarrhal fever?
- Acelphaline herpesvirus 1 and ovine herpesvirus 2 both lead to MCF within
- generalised catarrhal inflammation and necrotic lesions of mucous membranes
