Lecture 11

Question 1

What is the genome of Rhabdoviruses?

Answer 1

Negative sense single stranded RNA

Question 2

What type of virus is this?

Answer 2

Rhabdovirus

Question 3

Are Rhabdoviruses typically enveloped?

Answer 3

Yes

Question 4

Where does the replication of Rhabdoviruses occur?

Answer 4

Rhabdovirus replication is typically cytoplasmic

Question 5

Are Rhabdoviruses normally stable within their environment?

Answer 5

Typically Rhabdoviruses are relatively stable within their environment. However, they can be inactivated via the use of detergents

Question 6

What are the two major types of clinical rabies that are often described? What are their clinical symptoms?

Answer 6

Furious rabies = hyper-excitement + a tendancy to bite

Dumb rabies = characterised by depression and paralysis

Question 7

Brieftly describe the clinical course of Rabies within the host:

Answer 7

1. We get bitten
2. Sits in the muscle quietly- undergoes slow and quiet replication
3. Jumps into the end plates of our nerves- travels up the nerves and then enters the brain
4. Goes into our hindbrain
5. Goes into our salivary glands and this is typically where we will get transmission

Question 8

What is a usefull means of prevention of rabies within cattle?

Answer 8

Put anti-coagulants on the backs of the cattle that will lead to destruction of large amount of the population of the cattle

Question 9

Describe two techniques that are commonly used in the diagnosis of rabies:

Answer 9

• impression smears of the hippocampus of infected animals using Sellars stain and then examining for Negri Bodies
• Immunofluresence of viral antigen in the brain or spinal cord

Question 10

What are the two epidemiological forms of rabies rabies?

Answer 10

Urban Rabies- involving cats and dogs

Sylvatic Rabies- involving wild animals

Question 11

What genotype is the Australian Bat Lyssavirus (ABLV)?

Answer 11

Genotype 7