Lecture 7

Question 1

RANKL-OPG PATHWAY

Answer 1

OSTEOBLASTS => RANKL —> RANK RECEPTOR ON OSTEOCLAST (INACTIVE) —> TRIGGERS CHANGES IN OSTEOCLASTS THAT ACTIVATE THEM
I.E. RANKL PROMOTES BONE ABSORPTION
OSTEOPROTEGERIN (OPG) CONTRAINDICATES RANKL - STOPS IT FROM INTERACTING W/ RANK ON OSTEOCLAST => NO ACTIVATION AND A HALT IN BONE RESORPTION

Question 2

WOLFF’S LAW

Answer 2

BONES IN A HEALTHY PERSON WILL ADAPT TO LOADS UNDER WHICH THEY ARE FREQUENTLY APPLIED
*FORWARD/INVERSE BOTH TRUE - BONE GROWS MORE DENSE IN AREAS EXPERIENCING HIGH STRESS, WHILE RESORBING DENSITY IN AREAS OF LOW STRESS

Question 3

ALVEOLAR BONE LOSS

Answer 3

MANDIBLE = 4X BONE LOSS AS MAXILLA

Question 4

EDENTULISM

Answer 4

PREVALENCE - 26% OF US POPULATION AGES 65-74 ARE FULLY EDENTULOUS
38M PEOPLE EDENTULOUS BY 2020
230,000 DENTURES MADE/YEAR

Question 5

HEALTH EFFECTS OF EDENTULISM

Answer 5

CAUSES CHANGE IN DIET, INCREASED RISK FOR OBESITY, AND FULLY LEGALIZED DISABILITY BY W.H.O.
USE OF DENTURES CAN INCREASE ALVEOLAR BONE RESORPTION RATE
CAUSES LOSS OF FACIAL SUPPORT AND MUSCLE TONUS

Question 6

3RD DENTITION

Answer 6

FIXED DENTURE (NOW THE NORM TO USE AN IMPLANT ANCHORED DENTURE INSTEAD OF A REMOVABLE DENTURE)

Question 7

POST TOOTH XO

Answer 7

ALVEOLAR BONE LOSS:
WIDTH > HEIGHT

REPLACING W/ IMPLANTS CAUSES REGAINING OF FXN AND HALT IN BONE RESORPTION

Question 8

DURING RAT LACTATION

Answer 8

OSTEOCYTES ENLARGE - IE. EXHIBIT OSTEOCLASTIC ACTIVITY; HOWEVER, AFTER LACTATION THEY DEPOSIT BONE

SAME EXP ATTEMPTED W/ RAT SUSPENSION AND BONE UNLOADING; HOWEVER, ONLY LACTATION AND PREGNANCY CAN STIMULATE OSTEOCYTE ACTIVITY

Question 9

SIGNATURE ENZYME OF OSTEOCLASTS

Answer 9

TRAP